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      Effect of Growth Hormone Administration on the Fatty Acid Composition of Adipose Tissue in Growth-Hormone-Deficient Men

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          In adult patients with growth hormone deficiency, the fatty acid composition of abdominal and gluteal fat tissues was determined prior to and at several time points after administration of recombinant human growth hormone. Values obtained before growth hormone treatment were not different from those seen in a normal population. However, as in healthy individuals, significant differences were found in the composition of the fat sampled at the different sites. Administration of growth hormone had no effect on the composition. It is concluded that a change in fatty acid composition of fat tissue is unlikely to be a factor contributing to the reported increased cardiovascular mortality in hypopituitarism and that treatment with recombinant human growth hormone has no effect on that potential cardiovascular risk factor.

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          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          05 December 2008
          : 43
          : 6
          : 257-260
          aDepartment of Endocrinology and Metabolism, and bDepartment of Kinanthropometry, University of Ghent, Ghent, Belgium
          184304 Horm Res 1995;43:257–260
          © 1995 S. Karger AG, Basel

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          Pages: 4
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