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      Coordination of circadian timing in mammals.

      Nature

      physiology, Visual Pathways, Suprachiasmatic Nucleus, Photoreceptor Cells, Vertebrate, Phosphorylation, Models, Biological, genetics, Mammals, Light, Gene Expression Regulation, Feedback, Physiological, Circadian Rhythm, Animals, Active Transport, Cell Nucleus

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          Abstract

          Time in the biological sense is measured by cycles that range from milliseconds to years. Circadian rhythms, which measure time on a scale of 24 h, are generated by one of the most ubiquitous and well-studied timing systems. At the core of this timing mechanism is an intricate molecular mechanism that ticks away in many different tissues throughout the body. However, these independent rhythms are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world.

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          Journal
          12198538
          10.1038/nature00965

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