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      Coordination of circadian timing in mammals.

      1 ,
      Nature
      Springer Science and Business Media LLC

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          Abstract

          Time in the biological sense is measured by cycles that range from milliseconds to years. Circadian rhythms, which measure time on a scale of 24 h, are generated by one of the most ubiquitous and well-studied timing systems. At the core of this timing mechanism is an intricate molecular mechanism that ticks away in many different tissues throughout the body. However, these independent rhythms are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world.

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          Author and article information

          Journal
          Nature
          Nature
          Springer Science and Business Media LLC
          0028-0836
          0028-0836
          Aug 29 2002
          : 418
          : 6901
          Affiliations
          [1 ] Department of Neurobiology, University of Massachusetts Medical School, LRB-728, 364 Plantation Street, Worcester, Massachusetts 01605, USA. steven.reppert@umassmed.edu
          Article
          nature00965
          10.1038/nature00965
          12198538
          632368ff-8a04-4ff3-b620-16797cd7d920
          History

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