9
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Central administration of metastin increases food intake through opioid neurons in chicks.

      Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
      Animals, Chickens, Eating, drug effects, physiology, Humans, Injections, Intraventricular, Kisspeptins, Naltrexone, analogs & derivatives, pharmacology, Neurons, metabolism, Neuropeptides, administration & dosage, Receptors, Opioid, mu, antagonists & inhibitors, Tumor Suppressor Proteins

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Metastin, an RFamide peptide, has been isolated from human placenta and possesses several physiological actions in mammals. However, little is known about this bioactive peptide in avian species. This study was conducted to assess the effect of metastin on feeding behavior of chicks (Gallus gallus). The food intake of chicks is significantly increased by the intracerebroventricular injection of metastin. Beta-funaltrexamine, a mu-opioid receptor antagonist, significantly attenuates metastin-induced food intake in chicks. In contrast, delta- and kappa-opioid receptor antagonists did not show any influence on metastin-induced food intake in chicks. In addition, administration of N(G)-nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor, did not influence metastin-induced food intake. Taken together, this study shows the orexigenic effect of metastin in chicks and suggests that this effect is mediated by mu-opioid receptor.

          Related collections

          Author and article information

          Comments

          Comment on this article