Cell Biological Techniques and Cell-Biomaterial Interactions

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Abstract

Biomaterials play a key role in modern tissue engineering and regenerative medicine. They are expected to take over the function of a damaged tissue in the long term, trigger the self-healing potential of the body, and biodegrade at an appropriate rate. To meet these requirements, it is imperative to understand the cell-biomaterial interactions and develop new cell biotechnologies. The collection of this Special Issue brings together a number of studies portraying the underlying mechanisms of cell-biomaterial interactions.

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Nano based drug delivery systems: recent developments and future prospects

Jayanta Patra, Gitishree Das, Leonardo Fraceto … (2018)

Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner. Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific, and target-oriented delivery of precise medicines. Recently, there are a number of outstanding applications of the nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents etc.) in the treatment of various diseases. The current review, presents an updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs (e.g., natural products) and selective diagnosis through disease marker molecules. The opportunities and challenges of nanomedicines in drug delivery from synthetic/natural sources to their clinical applications are also discussed. In addition, we have included information regarding the trends and perspectives in nanomedicine area.

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Biomimetic materials for tissue engineering.

Peter Ma (2008)

Tissue engineering and regenerative medicine is an exciting research area that aims at regenerative alternatives to harvested tissues for transplantation. Biomaterials play a pivotal role as scaffolds to provide three-dimensional templates and synthetic extracellular matrix environments for tissue regeneration. It is often beneficial for the scaffolds to mimic certain advantageous characteristics of the natural extracellular matrix, or developmental or wound healing programs. This article reviews current biomimetic materials approaches in tissue engineering. These include synthesis to achieve certain compositions or properties similar to those of the extracellular matrix, novel processing technologies to achieve structural features mimicking the extracellular matrix on various levels, approaches to emulate cell-extracellular matrix interactions, and biologic delivery strategies to recapitulate a signaling cascade or developmental/wound healing program. The article also provides examples of enhanced cellular/tissue functions and regenerative outcomes, demonstrating the excitement and significance of the biomimetic materials for tissue engineering and regeneration.

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Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine

Domenico Lombardo, Mikhail Kiselev, Maria Teresa Caccamo (2019)

The study of nanostructured drug delivery systems allows the development of novel platforms for the efficient transport and controlled release of drug molecules in the harsh microenvironment of diseased tissues of living systems, thus offering a wide range of functional nanoplatforms for smart application in biotechnology and nanomedicine. This article highlights recent advances of smart nanocarriers composed of organic (including polymeric micelles and vesicles, liposomes, dendrimers, and hydrogels) and inorganic (including quantum dots, gold and mesoporous silica nanoparticles) materials. Despite the remarkable developments of recent synthetic methodologies, most of all nanocarriers’ action is associated with a number of unwanted side effects that diminish their efficient use in biotechnology and nanomedicine applications. This highlights some critical issues in the design and engineering of nanocarrier systems for biotechnology applications, arising from the complex environment and multiform interactions established within the specific biological media.

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Author and article information

Journal

Journal ID (nlm-ta): Cells

Journal ID (iso-abbrev): Cells

Journal ID (publisher-id): cells

Title: Cells

Publisher: MDPI

ISSN (Electronic): 2073-4409

Publication date (Electronic): 14 September 2020

Publication date Collection: September 2020

Volume: 9

Issue: 9

Electronic Location Identifier: 2094

Affiliations

[1 ]Department of Ocean and Mechanical Engineering, College of Computer Science and Engineering, Florida Atlantic University, Boca Raton, FL 33431, USA; kangy@ 123456fau.edu

[2 ]Department of Biomedical Science, College of Medicine, Florida Atlantic University, Boca Raton, FL 33431, USA

[3 ]Faculty of Integrative Biology PhD program, College of Science, Florida Atlantic University, Boca Raton, FL 33431, USA

Article

Publisher ID: cells-09-02094

DOI: 10.3390/cells9092094

PMC ID: 7563228

PubMed ID: 32937795

SO-VID: 633802b2-e230-4c7b-b27f-237170746a49

License:

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

Cell Biological Techniques and Cell-Biomaterial Interactions

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Abstract

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Gamma Delta T cells

Most cited references 15

Nano based drug delivery systems: recent developments and future prospects

Biomimetic materials for tissue engineering.

Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine

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