Biodegradable hollow manganese/cobalt oxide nanoparticles for tumor theranostics.

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Abstract

This article describes the fabrication of hollow manganese/cobalt oxide nanoparticles (MCO NPs) with a tunable size through a redox reaction and the Kirkendall effect for cancer imaging and drug delivery. MCO-70 NPs (with an average size of 70 nm) can act as glutathione (GSH)-responsive contrast agents for dual T1/T2-weighted magnetic resonance imaging (MRI). The degradation of MCO NPs by GSH led to the enhancement of their T1 and T2 signals by 2.24- and 3.43-fold compared with those of MCO NPs before degradation, respectively. Antitumor agents such as doxorubicin (Dox) could be encapsulated inside the cavity of the hollow MCO NPs (MCO-70-Dox) and be released in the presence of GSH. The MCO-70-Dox NPs showed good tumor growth inhibition effects in vitro and in vivo, and can be promising drug delivery vehicles and MRI contrast agents for tumor diagnosis and reporting drug release.

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Journal

Journal ID (iso-abbrev): Nanoscale

Title: Nanoscale

Publisher: Royal Society of Chemistry (RSC)

ISSN (Electronic): 2040-3372

ISSN (Print): 2040-3364

Publication date (Electronic): Dec 21 2019

Volume: 11

Issue: 47

Affiliations

[1 ] State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, China. rjzou@dhu.edu.cn hu.junqing@dhu.edu.cn.

[2 ] Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA. yijing.liu@nih.gov.

[3 ] Department of Neurosurgery, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China. doctorxiaozhi@163.com.

[4 ] Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China.

[5 ] College of Biology and the Environment, Co-Innovation Center for the Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu 210037, China.

Article

DOI: 10.1039/c9nr07725a

PubMed ID: 31774090

SO-VID: 6347dd07-53f3-44af-876f-0422ad20e11a

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