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      Lactobacilli as live vaccine delivery vectors: progress and prospects

      Trends in Biotechnology
      Elsevier BV

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          Abstract

          Evidence is accumulating that lactobacilli influence the immune response in a strain-dependent manner. This immunomodulatory capacity is important for the development of the immune response, and also identifies Lactobacillus as a potent oral vaccine carrier. Most of our current knowledge of the use of lactobacilli for vaccination purposes has been obtained with tetanus toxin fragment C (TTFC) as the model antigen. This knowledge, together with our ever-increasing understanding of the immune system and recent developments in cloning and expression techniques, should enable the utilisation of antigens other than TTFC and has made the development of lactobacilli as live vaccines a realistic prospect.

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          Author and article information

          Journal
          Trends in Biotechnology
          Trends in Biotechnology
          Elsevier BV
          01677799
          December 2002
          December 2002
          : 20
          : 12
          : 508-515
          Article
          10.1016/S0167-7799(02)02075-9
          12443872
          6354be4e-6d67-483f-9825-d8e8ef67ab89
          © 2002

          https://www.elsevier.com/tdm/userlicense/1.0/

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