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      Active sugar transport in health and disease

      , ,
      Journal of Internal Medicine
      Wiley

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          Abstract

          Secondary active glucose transport occurs by at least four members of the SLC5 gene family. This review considers the structure and function of two premier members, SGLT1 and SGLT2, and their role in intestinal glucose absorption and renal glucose reabsorption. Genetics disorders of SGLTs include Glucose-Galactose Malabsorption, and Familial Renal Glucosuria. SGLT1 plays a central role in Oral Rehydration Therapy used so effectively to treat secretory diarrhoea such as cholera. Increasing attention is being focused on SGLTs as drug targets for the therapy of diabetes.

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          Most cited references2

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          Physiology of the gastrointestinal tract

          Wright EM (2006)
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            Metabolic Basis of Inherited Disease

            Wright EM (2001)
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              Author and article information

              Journal
              Journal of Internal Medicine
              J Intern Med
              Wiley
              0954-6820
              1365-2796
              January 2007
              January 2007
              : 261
              : 1
              : 32-43
              Article
              10.1111/j.1365-2796.2006.01746.x
              17222166
              635bc564-13b5-489f-97f2-b385005884be
              © 2007

              http://doi.wiley.com/10.1002/tdm_license_1.1

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