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Abstract
Secondary active glucose transport occurs by at least four members of the SLC5 gene
family. This review considers the structure and function of two premier members, SGLT1
and SGLT2, and their role in intestinal glucose absorption and renal glucose reabsorption.
Genetics disorders of SGLTs include Glucose-Galactose Malabsorption, and Familial
Renal Glucosuria. SGLT1 plays a central role in Oral Rehydration Therapy used so effectively
to treat secretory diarrhoea such as cholera. Increasing attention is being focused
on SGLTs as drug targets for the therapy of diabetes.