Is ambient air pollution associated with onset of sudden infant death syndrome: a case-crossover study in the UK

Abstract

Objectives

Air pollution has been associated with increased mortality and morbidity in several studies with indications that its effect could be more severe in children. This study examined the relationship between short-term variations in criteria air pollutants and occurrence of sudden infant death syndrome (SIDS).

Design

We used a case-crossover study design which is widely applied in air pollution studies and particularly useful for estimating the risk of a rare acute outcome associated with short-term exposure.

Setting

The study used data from the West Midlands region in the UK.

Participants

We obtained daily time series data on SIDS mortality (ICD-9: 798.0 or ICD-10: R95) for the period 1996–2006 with a total of 211 SIDS events.

Primary outcome measures

Daily counts of SIDS events.

Results

For an IQR increase in previous day pollutant concentration, the percentage increases (95% CI) in SIDS were 16 (6 to 27) for PM ₁₀, 1 (−7 to 10) for SO ₂, 5 (−4 to 14) for CO, −17 (−27 to –6) for O ₃, 16 (2 to 31) for NO ₂ and 2 (−3 to 8) for NO after controlling for average temperature and national holidays. PM ₁₀ and NO ₂ showed relatively consistent association which persisted across different lag structures and after adjusting for copollutants.

Conclusions

The results indicated ambient air pollutants, particularly PM ₁₀ and NO ₂, may show an association with increased SIDS mortality. Thus, future studies are recommended to understand possible mechanistic explanations on the role of air pollution on SIDS incidence and the ways in which we might reduce pollution exposure among infants.