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      Neonatal Screening for Congenital Adrenal Hyperplasia Using a Microfilter Paper Method for 17-α-Hydroxyprogesterone Radioimmunoassay

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          Abstract

          We examined 22,233 infants born in Emilia-Romagna (Italy). Capillary blood samples for 17-OH-progesterone assay were collected on the 3rd, 4th, 5th, 6th or 7th day of life on filter paper of the same type used for the screening of aminoacidopathy and hypothyroidism. 17-OH-progesterone values were determined using a micromethod modified from that of Pang and co-workers. 20 pg/disk was considered as a threshold value and called for a second assay, which was performed in 0.18% of the cases. Pathologic values of 17-OH-progesterone were confirmed in the serum of 4 neonates. In our population the incidence of 21-hydroxylase deficiency was found to be 1 out of 5,558 cases.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1982
          1982
          25 November 2008
          : 16
          : 1
          : 4-9
          Affiliations
          a2nd Pediatric Clinic, University of Bologna, and bCentral Laboratory, S. Orsola Hospital of Bologna, Italy
          Article
          179479 Horm Res 1982;16:4–9
          10.1159/000179479
          7068111
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Paper

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