Persistence of Retinal Dopamine Cells in the Degenerated Eye of the Cave Salamander, Proteus anguinus L.

Abstract

The Proteus anguinus L. is a blind cave perennibranch amphibian whose visual system undergoes an important morphogenetic degeneration in adulthood. The eyeball becomes atrophied and disappears under the fat tissue of the head. However, a retina can still be identified and a photophobic behavior of the animal indicates a remaining photosen-sitivity. In the oldest animal observed, some photoreceptor cells are still present as well as other types of retinal neurons. Characteristic synapses are observed in both the inner and outer plexiform layers. Dopaminergic amacrine cells, with processes in the inner plexiform layer, can be identified by their tyrosine-hydroxylase immunoreactivity. Taken together, these results indicate a possible functional role of the remaining retina. Since dopamine is especially involved in light adaptation from darkness, the residual retina could act in triggering the turning behavior of Proteus in response to lightening.