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      Cellular, ultrastructural and molecular analyses of epidermal cell development in the planarian Schmidtea mediterranea

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          Abstract

          The epidermis is essential for animal survival, providing both a protective barrier and cellular sensor to external environments. The generally conserved embryonic origin of the epidermis, but the broad morphological and functional diversity of this organ across animals is puzzling. We define the transcriptional regulators underlying epidermal lineage differentiation in the planarian Schmidtea mediterranea, an invertebrate organism that, unlike fruitflies and nematodes, continuously replaces its epidermal cells. We find that Smed-p53, Sox and Pax transcription factors are essential regulators of epidermal homeostasis, and act cooperatively to regulate genes associated with early epidermal precursor cell differentiation, including a tandemly arrayed novel gene family ( prog) of secreted proteins. Additionally, we report on the discovery of distinct and previously undescribed secreted organelles whose production is dependent on the transcriptional activity of soxP-3, and which we term Hyman vesicles.

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          Author and article information

          Journal
          0372762
          3389
          Dev Biol
          Dev. Biol.
          Developmental biology
          0012-1606
          1095-564X
          15 September 2017
          31 October 2017
          15 January 2018
          15 January 2019
          : 433
          : 2
          : 357-373
          Affiliations
          [1 ]Stowers Institute for Medical Research, Kansas City, United States
          [2 ]Howard Hughes Medical Institute, Stowers Institute for Medical Research, Kansas City, United States
          Author notes
          [* ]Corresponding author. asa@ 123456stowers.org
          Article
          PMC5750087 PMC5750087 5750087 nihpa906402
          10.1016/j.ydbio.2017.08.030
          5750087
          29100657
          Categories
          Article

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