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      Molecular mechanisms and biological role of Campylobacter jejuni attachment to host cells

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          Abstract

          Adhesion to host cells is an important step in pathogenesis of Campylobacter jejuni, which is the most prevalent bacterial cause of human gastroenteritis worldwide. In contrast to other bacteria such as E. coli and Salmonella, adherence of C. jejuni is not mediated by fimbria or pili. A number of C. jejuni adhesion-related factors have been described. However, the results obtained by different researchers in different laboratories are often contradictory and inconclusive, with only some of the factors described being confirmed as true adhesins. In this review, we present the current state of studies on the mechanisms of attachment of C. jejuni to host cells.

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          Bacterial adhesion and entry into host cells.

          Javier Pizarro-Cerdá, Pascale Cossart (2006)
          Successful establishment of infection by bacterial pathogens requires adhesion to host cells, colonization of tissues, and in certain cases, cellular invasion-followed by intracellular multiplication, dissemination to other tissues, or persistence. Bacteria use monomeric adhesins/invasins or highly sophisticated macromolecular machines such as type III secretion systems and retractile type IV pili to establish a complex host/pathogen molecular crosstalk that leads to subversion of cellular functions and establishment of disease.
          Article 0 comments Cited 267 times – based on 0 reviews     Review now
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            Campylobacter jejuni: molecular biology and pathogenesis.

            Kathryn Young, Lindsay Davis, Victor J. DiRita (2007)
            Campylobacter jejuni is a foodborne bacterial pathogen that is common in the developed world. However, we know less about its biology and pathogenicity than we do about other less prevalent pathogens. Interest in C. jejuni has increased in recent years as a result of the growing appreciation of its importance as a pathogen and the availability of new model systems and genetic and genomic technologies. C. jejuni establishes persistent, benign infections in chickens and is rapidly cleared by many strains of laboratory mouse, but causes significant inflammation and enteritis in humans. Comparing the different host responses to C. jejuni colonization should increase our understanding of this organism.
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              Protein-glycan interactions in the control of innate and adaptive immune responses.

              Yvette van Kooyk, Gabriel Rabinovich (2008)
              The importance of protein glycosylation in the migration of immune cells throughout the body has been extensively appreciated. However, our awareness of the impact of glycosylation on the regulation of innate and adaptive immune responses is relatively new. An increasing number of studies reveal the relevance of glycosylation to pathogen recognition, to the modulation of the innate immune system and to the control of immune cell homeostasis and inflammation. Similarly important is the effect of glycan-containing 'information' in the development of autoimmune diseases and cancer. In this review, we provide an overview of these new directions and their impact in the field of glycoimmunology.
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                Author and article information

                Journal
                Journal ID (publisher-id): 1886
                Journal ID (MPID): 122234
                Title: European Journal of Microbiology and Immunology
                Abbreviated Title: EuJMI
                Publisher: Akadémiai Kiadó, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic Publishers B.V.
                ISSN (Print): 2062-509X
                ISSN (Electronic): 2062-8633
                Publication date (Print): 1 March 2012
                Volume: 2
                Issue: 1
                Pages: 32-40
                Affiliations
                [ 1 ] School of Life Sciences, Faculty of Science, Engineering and Computing, Kingston University, Penrhyn Road, Kingston upon Thames, KT1 2EE, UK
                Author notes
                [* ] +44 (0)20 8417 7405, +44 (0)20 8417 7497, a.karlyshev@ 123456kingston.ac.uk
                Article
                Other ID: 6
                DOI: 10.1556/EuJMI.2.2012.1.6
                PMC ID: 3933988
                PubMed ID: 24611119
                SO-VID: 63935f55-18a9-49f1-879b-044d6c9ad865
                History
                Date received : 3 January 2012
                Date accepted : 4 January 2012
                Categories
                Subject: Reviews

                ScienceOpen disciplines: Medicine,Immunology,Health & Social care,Microbiology & Virology,Infectious disease & Microbiology
                Keywords: host cell receptors,glycoproteins,evasion of immune response,pathogenesis,adhesins, Campylobacter jejuni ,adhesion,attachment,colonisation
                Data availability:
                ScienceOpen disciplines: Medicine, Immunology, Health & Social care, Microbiology & Virology, Infectious disease & Microbiology
                Keywords: host cell receptors, glycoproteins, evasion of immune response, pathogenesis, adhesins, Campylobacter jejuni , adhesion, attachment, colonisation

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