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Dendritic actin filament nucleation causes traveling waves and patches.

Physical review letters

Protein Structure, Quaternary, Protein Multimerization, Movement, Models, Molecular, Feedback, Physiological, metabolism, chemistry, Dendrimers, Cell Membrane, Actins, Actin Cytoskeleton

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      Abstract

      The polymerization of actin via branching at a cell membrane containing nucleation-promoting factors is simulated using a stochastic-growth methodology. The polymerized-actin distribution displays three types of behavior: (a) traveling waves, (b) moving patches, and (c) random fluctuations. Increasing actin concentration causes a transition from patches to waves. The waves and patches move by a treadmilling mechanism not involving myosin II. The effects of downregulation of key proteins on actin wave behavior are evaluated.

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      2947330
      20867207

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