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      Challenging issues in molecular-targeted therapy

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          Abstract

          There are variety of anticancer treatments including chemotherapeutic drugs, which are known to induce cell growth arrest and apoptosis through DNA damage and cytoskeleton toxicity. Meanwhile, histone deacetylase (HDAC) inhibitors could apply their antitumor activity through chromatin remodeling and gene expression modulation that affect the cell cycle and survival pathways. This paper proposes an anticancer three-drug compound and discusses several challenging issues in relation to designing multidrug compounds that could possibly lead to molecular-targeted therapies.

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          Author and article information

          Journal
          Ther Clin Risk Manag
          Therapeutics and Clinical Risk Management
          Therapeutics and Clinical Risk Management
          Dove Medical Press
          1176-6336
          1178-203X
          2009
          2009
          26 March 2009
          : 5
          : 239-245
          Affiliations
          Applied Science and Technology, Higher Colleges of Technology, Al Ain, United Arab Emirates
          Author notes
          Correspondence: Zoheir Ezziane, Applied Science and Technology, Higher Colleges of Technology, PO Box 17258 Al Ain, United Arab Emirates, Tel +97 137 095 229, Fax +97 137 820 766, Email zoheir.ezziane@ 123456hct.ac.ae
          Article
          tcrm-5-0239
          2697511
          19436605
          © 2009 Ezziane, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

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