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      Acquired von Willebrand syndrome: an update.

      American Journal of Hematology

      therapeutic use, metabolism, immunology, chemistry, von Willebrand Factor, therapy, physiopathology, etiology, diagnosis, chemically induced, blood, von Willebrand Diseases, Immunoglobulins, Intravenous, Humans, complications, Hematologic Diseases, Factor VIII, Endocrine System Diseases, Deamino Arginine Vasopressin, Cardiovascular Diseases, Blood Coagulation Tests, Autoimmune Diseases, Autoantibodies, Adsorption, ADAM Proteins

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          Abstract

          Acquired von Willebrand syndrome (aVWS) is a rare bleeding disorder with laboratory findings similar to those for congenital von Willebrand disease (VWD). However, unlike congenital VWD, it arises in individuals with no personal or family history of bleeding. aVWS occurs in association with a variety of underlying disorders, most frequently in lymphoproliferative disorders, myeloproliferative disorders, and cardiovascular diseases. Through an analysis of the more recent literature data, the pathophysiology and the clinical, laboratory, and therapeutic aspects of this syndrome are concisely reported in this review. (c) 2006 Wiley-Liss, Inc.

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          Journal
          10.1002/ajh.20830
          17133419

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