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      Environmentally induced epigenetic transgenerational inheritance of disease susceptibility.

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          Abstract

          Environmental insults, such as exposure to toxicants or nutritional abnormalities, can lead to epigenetic changes that are in turn related to increased susceptibility to disease. The focus of this review is on the transgenerational inheritance of such epigenetic abnormalities (epimutations), and how it is that these inherited epigenetic abnormalities can lead to increased disease susceptibility, even in the absence of continued environmental insult. Observations of environmental toxicant specificity and exposure-specific disease susceptibility are discussed. How epimutations are transmitted across generations and how epigenetic changes in the germline are translated into an increased disease susceptibility in the adult is reviewed with regard to disease etiology.

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          Author and article information

          Journal
          Transl Res
          Translational research : the journal of laboratory and clinical medicine
          1878-1810
          1878-1810
          Jan 2015
          : 165
          : 1
          Affiliations
          [1 ] Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, Wash.
          [2 ] Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, Wash. Electronic address: skinner@wsu.edu.
          Article
          S1931-5244(14)00077-2 NIHMS571592
          10.1016/j.trsl.2014.02.003
          24657180
          63cdec55-d6eb-4532-b0db-7b0ef3f98edc
          Copyright © 2015 Elsevier Inc. All rights reserved.
          History

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