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      Relaxant Effects of Vasoactive Intestinal Peptide and Peptide Histidine Isoleucine in Human and Bovine Pulmonary Arteries

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          We studied the functional effects of vasoactive intestinal peptide (VIP) and the structurally related peptide histidine isoleucine (PHI) in segments of bovine and human intrapulmonary artery. In both species, VIP caused nearly complete relaxation of precontracted vessel segments. The EC<sub>50</sub> was 1.3 ± 0.3 × 10<sup>–9</sup> M (mean ± SD) in bovine and 3.4 ± 0.4 × 10<sup>–9</sup> M in human pulmonary artery. The response to VIP was not endothelium-dependent and it was not affected by either adrenergic and cholinergic blockade or by cyclooxygenase inhibition. PHI also relaxed human and bovine vessels but this related peptide was significantly less effective than VIP. We conclude that VIP is a potent inhibitor of bovine and human pulmonary artery, which appears to act directly on vascular smooth muscle. These data support the concept that VIP may be a neurotransmitter which modulates pulmonary artery tone in both man and cow.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          23 September 2008
          : 24
          : 1-2
          : 45-50
          Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
          158670 Blood Vessels 1987;24:45–50
          © 1987 S. Karger AG, Basel

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          Pages: 6
          Research Paper


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