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      Topical wound anaesthesia: efficacy to mitigate piglet castration pain

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          Abstract

          Objective

          There is a critical need for safe and effective analgesic treatments to address pain resulting from surgical husbandry procedures in livestock. Piglet castration results in acute pain and stress to the animal; however, it is performed globally on millions of piglets annually, often without any analgesia what‐so‐ever. Tri‐Solfen® (Animal Ethics Pty Ltd, Yarra Glen, Victoria, Australia) is a combination local anaesthetic and antiseptic formulation which, applied topically to wounds, has proven effective, and is registered for use to alleviate pain associated with castration (and other wounds) in lambs and calves in Australia and New Zealand. It is also reported to be effective to reduce pain in piglets following castration.

          Design

          This randomised, blinded, placebo‐controlled study examined the safety and efficacy of the formulation, administered via an adapted wound instillation method, to control pain both during and following piglet castration.

          Method

          Piglets received Tri‐Solfen or placebo, instilled to the wound immediately following skin incision. A 30 s wait period was then observed prior to completing castration. Pain mitigation was assessed by grading nociceptive resistance movements and piglet vocal response during castration, as well as by grading response to mechanical sensory stimulation of the wound (von Frey and needlestick) following castration.

          Results

          There was a significant reduction in nociceptive motor and vocal response during castration and in response to mechanical sensory wound stimulation up to and including 2 h following castration. There were no adverse events.

          Conclusion

          Administered via this method, Tri‐Solfen is effective to mitigate acute peri‐operative castration pain in piglets.

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          Most cited references25

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          Vocal response to pain in piglets

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            Castration induced pain in pigs and other livestock

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              Analysis of pain-related vocalization in young pigs

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                Author and article information

                Contributors
                baysheil@bigpond.net.au
                Journal
                Aust Vet J
                Aust. Vet. J
                10.1111/(ISSN)1751-0813
                AVJ
                Australian Veterinary Journal
                Wiley Publishing Asia Pty Ltd (Melbourne )
                0005-0423
                1751-0813
                24 February 2020
                June 2020
                : 98
                : 6 ( doiID: 10.1111/avj.v98.6 )
                : 256-263
                Affiliations
                [ 1 ] Animal Ethics Pty Ltd Yarra Glen Victoria 3775 Australia
                [ 2 ] Invetus Pty Ltd Armidale New South Wales 2350 Australia
                Author notes
                [*] [* ] Corresponding author.

                baysheil@ 123456bigpond.net.au

                Author information
                https://orcid.org/0000-0002-6596-2265
                Article
                AVJ12930
                10.1111/avj.12930
                7384076
                32096229
                64000eb4-b831-4d3c-81e5-5d199c3dc1b2
                © 2020 The Authors. Australian Veterinary Journal published by John Wiley & Sons Australia, Ltd on behalf of Australian Veterinary Association.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

                History
                : 06 December 2019
                : 25 January 2020
                : 28 January 2020
                Page count
                Figures: 5, Tables: 3, Pages: 8, Words: 6670
                Funding
                Funded by: Animal Ethics Pty Ltd
                Categories
                Original Article
                Production
                Custom metadata
                2.0
                June 2020
                Converter:WILEY_ML3GV2_TO_JATSPMC version:5.8.6 mode:remove_FC converted:27.07.2020

                animal welfare,castration,local anaesthesia,pain management,pigs

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