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      Influence of INF-gamma gene polymorphism in HTLV-1 proviral load

      , 1 , 2 , 1 , 3 , 2 , 1 , 2 , 2 , 1 , 2 , 1 , 3

      Retrovirology

      BioMed Central

      15th International Conference on Human Retroviruses: HTLV and Related Viruses

      5-8 June 2011

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          Abstract

          Background Interferon-gamma (INF-γ) is a key cytokine involved in the defense against intracellular pathogens, such as HTLV-1, by coordinating the expression of immunologically relevant genes. Previous studies showed the importance of this cytokine on HTLV-1-related pathogenesis. Thus, we have investigated the possible association between IFN-γ gene single-nucleotide polymorphism linked to high and low producer phenotypes (IFN-γ [+874T(high) → A(low)]) and risk of development of symptoms related with HTLV-1 infection and proviral load. Methods The polymorphism +874 T/A of INF-γ was analyzed by PCR-SSP in 93 patients HLTV-1 positive (HAC + HAM), stratified according to the presence (HAM, n = 50) or not (HAC, n = 43) of symptoms, and healthy controls (n = 150). Proviral load of infected patients (HAC and HAM) was determined by real-time PCR. Results No significant difference was observed for allelic and genotypic frequencies of the +874T/A polymorphism of INF-γ when correlated with HAC, HAM and healthy controls groups. The median of proviral load was lower in HAC than HAM group (p=0.0131). Also, the p-value is very close to significance (p=0.0523) for +874TT genotype (high producer of INF-γ) and low proviral load, compared to the genotypes +874AA and +874AT. Conclusion Despite the lack of significant associations, the low proviral load appears correlated with high producer of INF-γ (+874TT) genotype. Increasing the number of patients may lead to statistical relationship of the +874TT genotype with low proviral load.

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          Author and article information

          Conference
          Retrovirology
          Retrovirology
          BioMed Central
          1742-4690
          2011
          6 June 2011
          : 8
          : Suppl 1
          : A119
          Affiliations
          [1 ]Regional Blood Center of Ribeirão Preto, Ribeirão Preto, Brazil
          [2 ]Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil
          [3 ]Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil
          Article
          1742-4690-8-S1-A119
          10.1186/1742-4690-8-S1-A119
          3112586
          Copyright ©2011 Haddad et al; licensee BioMed Central Ltd.

          This is an open access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

          15th International Conference on Human Retroviruses: HTLV and Related Viruses
          Leuven and Gembloux, Belgium
          5-8 June 2011
          Categories
          Meeting Abstract

          Microbiology & Virology

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