Ex vivo γH2AX radiation sensitivity assay in prostate cancer: Inter-patient and intra-patient heterogeneity.

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Abstract

The aim of the study is to assess inter-patient and intra-patient heterogeneity in tumour cell radiosensitivity using the ex vivo γH2AX assay in prostate cancer specimens.

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Journal

Journal ID (iso-abbrev): Radiother Oncol

Title: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Publisher: Elsevier BV

ISSN (Electronic): 1879-0887

ISSN (Print): 0167-8140

Publication date (Electronic): September 2017

Volume: 124

Issue: 3

Affiliations

[1 ] Medical Faculty and University Hospital, Eberhard Karls University Tübingen, Radiation Oncology, Germany.

[2 ] Radiation Oncology (Maastro), GROW-School for Oncology and Developmental Biology, Maastricht, The Netherlands.

[3 ] Medical Faculty and University Hospital, Eberhard Karls University Tübingen, Urology, Germany.

[4 ] The University of Texas MD Anderson Cancer Center, Department of Biostatistics, Houston, USA.

[5 ] Medical Faculty and University Hospital, Eberhard Karls University Tübingen, Pathology, Germany.

[6 ] Department of Oncology, Radiation Oncology, University of Turin, Italy.

[7 ] German Cancer Research Center (DKFZ), Heidelberg and German Cancer Consortium (DKTK), Germany.

[8 ] Medical Faculty and University Hospital, Eberhard Karls University Tübingen, Radiation Oncology, Germany; German Cancer Consortium (DKTK), partner site Tübingen, and German Cancer Research Center (DKFZ), Heidelberg, Germany.

[9 ] Medical Faculty and University Hospital, Eberhard Karls University Tübingen, Radiation Oncology, Germany. Electronic address: a.menegakis@nki.nl.

Article

Publisher Item ID: S0167-8140(17)32543-4

DOI: 10.1016/j.radonc.2017.08.020

PubMed ID: 28919005

SO-VID: 642a630a-cd03-4129-a8d0-23c82b51b2ad

History

Keywords: Intrinsic radiation sensitivity,Personalized radiation oncology,Prostate cancer,γH2AX foci,Ex vivo,Inter-patient variability,Intra-patient variability

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Keywords: Intrinsic radiation sensitivity, Personalized radiation oncology, Prostate cancer, γH2AX foci, Ex vivo, Inter-patient variability, Intra-patient variability

Ex vivo γH2AX radiation sensitivity assay in prostate cancer: Inter-patient and intra-patient heterogeneity.

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