For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
57
views
130
references
 Top references
cited by
63
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      69
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Deciphering the Role of Phytoalexins in Plant-Microorganism Interactions and Human Health

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Phytoalexins are low molecular weight antimicrobial compounds that are produced by plants as a response to biotic and abiotic stresses. As such they take part in an intricate defense system which enables plants to control invading microorganisms. In this review we present the key features of this diverse group of molecules, namely their chemical structures, biosynthesis, regulatory mechanisms, biological activities, metabolism and molecular engineering.

          Related collections

          Most cited references130

          • Record: found
          • Abstract: found
          • Article: not found

          Sirtuin activators mimic caloric restriction and delay ageing in metazoans.

          Jason Wood, Blanka Rogina, Siva Lavu … (2004)
          Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases. Sirtuin activating compounds (STACs) can promote the survival of human cells and extend the replicative lifespan of yeast. Here we show that resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals without reducing fecundity. Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction.
          Article 0 comments Cited 451 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Phytoalexins in defense against pathogens.

            Ishita Ahuja, Ralph Kissen, Atle M. Bones (2012)
            Plants use an intricate defense system against pests and pathogens, including the production of low molecular mass secondary metabolites with antimicrobial activity, which are synthesized de novo after stress and are collectively known as phytoalexins. In this review, we focus on the biosynthesis and regulation of camalexin, and its role in plant defense. In addition, we detail some of the phytoalexins produced by a range of crop plants from Brassicaceae, Fabaceae, Solanaceae, Vitaceae and Poaceae. This includes the very recently identified kauralexins and zealexins produced by maize, and the biosynthesis and regulation of phytoalexins produced by rice. Molecular approaches are helping to unravel some of the mechanisms and reveal the complexity of these bioactive compounds, including phytoalexin action and metabolism. Copyright © 2011 Elsevier Ltd. All rights reserved.
            Article 0 comments Cited 324 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Salicylic acid induction-deficient mutants of Arabidopsis express PR-2 and PR-5 and accumulate high levels of camalexin after pathogen inoculation.

              C Nawrath, J P Métraux (1999)
              In Arabidopsis, systemic acquired resistance against pathogens has been associated with the accumulation of salicylic acid (SA) and the expression of the pathogenesis-related proteins PR-1, PR-2, and PR-5. We report here the isolation of two nonallelic mutants impaired in the pathway leading to SA biosynthesis. These SA induction-deficient (sid) mutants do not accumulate SA after pathogen inoculation and are more susceptible to both virulent and avirulent forms of Pseudomonas syringae and Peronospora parasitica. However, sid mutants are not as susceptible to these pathogens as are transgenic plants expressing the nahG gene encoding an SA hydroxylase that degrades SA to catechol. In contrast to NahG plants, only the expression of PR-1 is strongly reduced in sid mutants, whereas PR-2 and PR-5 are still expressed after pathogen attack. Furthermore, the accumulation of the phytoalexin camalexin is normal. These results indicate that SA-independent compensation pathways that do not operate in NahG plants are active in sid mutants. One of the mutants is allelic to eds5 (for enhanced disease susceptibility), whereas the other mutant has not been described previously.
              Article 0 comments Cited 180 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Derek J. McPhee: Role: External Editor
                Journal
                Journal ID (nlm-ta): Molecules
                Journal ID (iso-abbrev): Molecules
                Journal ID (publisher-id): molecules
                Title: Molecules
                Publisher: MDPI
                ISSN (Electronic): 1420-3049
                Publication date (Electronic): 05 November 2014
                Publication date Collection: November 2014
                Volume: 19
                Issue: 11
                Pages: 18033-18056
                Affiliations
                [1 ]Laboratory of Stress, Defenses and Plant Reproduction, Research Unit “Vines and Wines of Champagne”, UPRES EA 4707, Department of Biology and Biochemistry, Faculty of Sciences, University of Reims, P.O. Box 1039, 51687 Reims cedex 02, France; E-Mails: claire.hebrard@ 123456univ-reims.fr (C.H.); sylvain.cordelier@ 123456univ-reims.fr (S.C.); stephan.dorey@ 123456univ-reims.fr (S.D.); aziz.aziz@ 123456univ-reims.fr (A.A.); jerome.crouzet@ 123456univ-reims.fr (J.C.)
                [2 ]Champagne Deville, 13 rue Carnot, Verzy 51380, France; E-Mail: mdevillegarrick@ 123456gmail.com
                Author notes
                [* ]Author to whom correspondence should be addressed; E-Mail: philippe.jeandet@ 123456univ-reims.fr ; Tel.: +33-3-2691-3341; Fax: +33-3-2691-3340.
                Article
                Publisher ID: molecules-19-18033
                DOI: 10.3390/molecules191118033
                PMC ID: 6271817
                PubMed ID: 25379642
                SO-VID: 645e60ee-b106-4121-9167-8c9de1debcd4
                Copyright © © 2014 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 17 September 2014
                Date revision received : 29 October 2014
                Date accepted : 29 October 2014
                Categories
                Subject: Review

                Keywords: phytoalexins,plants,defense mechanisms,microorganisms,biological activity
                Data availability:
                Keywords: phytoalexins, plants, defense mechanisms, microorganisms, biological activity

                Comments

                Comment on this article

                scite_

                Similar content69

                See all similar

                Cited by60

                See all cited by

                Most referenced authors1,161

                See all reference authors