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      Comparison of two confocal microscopes for diagnosis of acanthamoeba keratitis

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          Most cited references 5

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          Clinical in vivo confocal microscopy of the human cornea in health and disease.

          Confocal microscopy enables microstructural analysis of the in vivo cornea, allowing fresh insight into corneal microstructure in health, and in inherited and acquired corneal disease. This method of corneal examination is evolving in an exponential fashion, with rapid advances in technology being mirrored by rapid growth in both research and clinical applications. Whilst initially the evidence base for in vivo confocal microscopy consisted largely of small case studies, in recent years there has been a trend towards collecting quantitative data in an effort to better delineate between heath and disease. Confocal microscopy has been utilised clinically to aid in the diagnosis of infectious keratitis, in particular Acanthamoeba and fungal keratitis, and has also established a role in the diagnosis and phenotyping of corneal dystrophies. This article reviews in vivo confocal microscopy of the human cornea in health and disease and examines clinical and research applications of this new technology.
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            Update on Acanthamoeba Keratitis

            A literature review to describe the current diagnosis and management of Acanthamoeba keratitis.
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              Current state of in vivo confocal microscopy in management of microbial keratitis.

              The purpose of this study was to review the current literature on in vivo confocal microscopy of the cornea and to discuss the current clinical indications for its use in microbial keratitis. Review of select recent literature on in vivo confocal microscopy and atypical microbial keratitis. Delayed diagnosis of Acanthamoeba and fungal keratitis is typical, resulting in significant vision loss. This is partially due to the low sensitivity and time delay of corneal cultures. In the hands of an experienced viewer, the confocal microscope has been found to have a sensitivity of up to 90% in the diagnosis of Acanthamoeba keratitis and close to 80% for fungal keratitis. In vivo confocal microscopy is emerging as a tool for rapid diagnoses in severe infectious keratitis with high sensitivity. In addition, it can be used to monitor treatment response, allowing guidance to clinicians for medical or surgical management.
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                Author and article information

                Contributors
                (View ORCID Profile)
                Journal
                Eye
                Eye
                Springer Science and Business Media LLC
                0950-222X
                1476-5454
                August 5 2020
                Article
                10.1038/s41433-020-1117-4
                © 2020

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