Altered vaginal microbiome and relative co-abundance network in pregnant women with penicillin allergy

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Abstract

Background

Penicillin allergy is frequently reported in adults and children. Recent studies suggest that microbiota plays a key role in the development and progression of allergy. In this study, the relationship between vaginal microbiome and pregnant women with penicillin allergy was investigated.

Methods

Vaginal samples before labor from 12 pregnant women with penicillin allergy and 15 non-allergic pregnant women were collected. Bacterial community structure of all study subjects and the discrepancies between the two groups were analyzed using 16S rRNA sequencing based on Illumina Hiseq 2500 platform.

Results

The abundant phyla among all participants were Firmicutes, Actinobacteria and Bacteroidetes. The predominant genus was Lactobacillus. Compared to non-allergic pregnant women, Actinobacteria, Coriobacteriaceae, Lachnospiraceae, Paraprevotella and Anoxybacillus significantly decreased, whereas Deltaproteobacteria, Peptostreptococcaceae, Enterococcus and Megamonas were more abundant in penicillin allergic women. Additionally, obvious discrepancies were observed in the co-abundance network at the genus level between the two groups.

Conclusions

There were differences in the microbial community structure and composition of reproduction tract between penicillin allergic and non-allergic pregnant women. These shifts may be related to maternal and neonatal health.

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Most cited references 31

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Low gut microbiota diversity in early infancy precedes asthma at school age.

T. Abrahamsson, H. Jakobsson, A. Andersson … (2014)

Low total diversity of the gut microbiota during the first year of life is associated with allergic diseases in infancy, but little is known how early microbial diversity is related to allergic disease later in school age. To assess microbial diversity and characterize the dominant bacteria in stool during the first year of life in relation to the prevalence of different allergic diseases in school age, such as asthma, allergic rhinoconjunctivitis (ARC) and eczema. The microbial diversity and composition was analysed with barcoded 16S rDNA 454 pyrosequencing in stool samples at 1 week, 1 month and 12 months of age in 47 infants which were subsequently assessed for allergic disease and skin prick test reactivity at 7 years of age (ClinicalTrials.gov ID NCT01285830). Children developing asthma (n = 8) had a lower diversity of the total microbiota than non-asthmatic children at 1 week (P = 0.04) and 1 month (P = 0.003) of age, whereas allergic rhinoconjunctivitis (n = 13), eczema (n = 12) and positive skin prick reactivity (n = 14) at 7 years of age did not associate with the gut microbiota diversity. Neither was asthma associated with the microbiota composition later in infancy (at 12 months). Children having IgE-associated eczema in infancy and subsequently developing asthma had lower microbial diversity than those that did not. There were no significant differences, however, in relative abundance of bacterial phyla and genera between children with or without allergic disease. Low total diversity of the gut microbiota during the first month of life was associated with asthma but not ARC in children at 7 years of age. Measures affecting microbial colonization of the infant during the first month of life may impact asthma development in childhood. © 2013 John Wiley & Sons Ltd.

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Low diversity of the gut microbiota in infants with atopic eczema.

Thomas R Abrahamsson, Hedvig E Jakobsson, Anders F. Andersson … (2012)

It is debated whether a low total diversity of the gut microbiota in early childhood is more important than an altered prevalence of particular bacterial species for the increasing incidence of allergic disease. The advent of powerful, cultivation-free molecular methods makes it possible to characterize the total microbiome down to the genus level in large cohorts. We sought to assess microbial diversity and characterize the dominant bacteria in stool during the first year of life in relation to atopic eczema development. Microbial diversity and composition were analyzed with barcoded 16S rDNA 454-pyrosequencing in stool samples at 1 week, 1 month, and 12 months of age in 20 infants with IgE-associated eczema and 20 infants without any allergic manifestation until 2 years of age (ClinicalTrials.gov ID NCT01285830). Infants with IgE-associated eczema had a lower diversity of the total microbiota at 1 month (P = .004) and a lower diversity of the bacterial phylum Bacteroidetes and the genus Bacteroides at 1 month (P = .02 and P = .01) and the phylum Proteobacteria at 12 months of age (P = .02). The microbiota was less uniform at 1 month than at 12 months of age, with a high interindividual variability. At 12 months, when the microbiota had stabilized, Proteobacteria, comprising gram-negative organisms, were more abundant in infants without allergic manifestation (Empirical Analysis of Digital Gene Expression in R [edgeR] test: P = .008, q = 0.02). Low intestinal microbial diversity during the first month of life was associated with subsequent atopic eczema. Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

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Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age.

Hans Bisgaard, Nan Li, Klaus Bonnelykke … (2011)

Changes in the human microbiome have been suggested as a risk factor for a number of lifestyle-related disorders, such as atopic diseases, possibly through a modifying influence on immune maturation in infancy. We aimed to explore the association between neonatal fecal flora and the development of atopic disorders until age 6 years, hypothesizing that the diversity of the intestinal microbiota influences disease development. We studied the intestinal microbiota in infants in the Copenhagen Prospective Study on Asthma in Childhood, a clinical study of a birth cohort of 411 high-risk children followed for 6 years by clinical assessments at 6-month intervals, as well as at acute symptom exacerbations. Bacterial flora was analyzed at 1 and 12 months of age by using molecular techniques based on 16S rRNA PCR combined with denaturing gradient gel electrophoresis, as well as conventional culturing. The main outcome measures were the development of allergic sensitization (skin test and specific serum IgE), allergic rhinitis, peripheral blood eosinophil counts, asthma, and atopic dermatitis during the first 6 years of life. We found that bacterial diversity in the early intestinal flora 1 and 12 months after birth was inversely associated with the risk of allergic sensitization (serum specific IgE P = .003; skin prick test P = .017), peripheral blood eosinophils (P = .034), and allergic rhinitis (P = .007). There was no association with the development of asthma or atopic dermatitis. Reduced bacterial diversity of the infant's intestinal flora was associated with increased risk of allergic sensitization, allergic rhinitis, and peripheral blood eosinophilia, but not asthma or atopic dermatitis, in the first 6 years of life. These results support the general hypothesis that an imbalance in the intestinal microbiome is influencing the development of lifestyle-related disorders, such as allergic disease. Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

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Author and article information

Contributors

Yong Zhang: zy.203@163.com

Journal

Journal ID (nlm-ta): Allergy Asthma Clin Immunol

Journal ID (iso-abbrev): Allergy Asthma Clin Immunol

Title: Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology

Publisher: BioMed Central (London )

ISSN (Print): 1710-1484

ISSN (Electronic): 1710-1492

Publication date (Electronic): 9 September 2020

Publication date PMC-release: 9 September 2020

Publication date Collection: 2020

Volume: 16

Electronic Location Identifier: 79

Affiliations

[1 ]GRID grid.54549.39, ISNI 0000 0004 0369 4060, Chengdu Women’s and Children’s Central Hospital, School of Medicine, , University of Electronic Science and Technology of China, ; Chengdu, 610000 China

[2 ]GRID grid.258164.c, ISNI 0000 0004 1790 3548, Shenzhen Baoan Women’s and Children’s Hospital, Jinan University, ; Shenzhen, 518000 China

[3 ]GRID grid.459579.3, Guangdong Women and Children Hospital, ; No. 13, Guangyuan West Road, Yuexiu District, Guangzhou, 510000 China

[4 ]GRID grid.452787.b, ISNI 0000 0004 1806 5224, Shenzhen Children’s Hospital, ; Shenzhen, 518000 China

Article

Publisher ID: 475

DOI: 10.1186/s13223-020-00475-5

PMC ID: 7491301

PubMed ID: 32944033

SO-VID: 64903f1e-24d7-42da-82c5-a59863885f75

License:

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

History

Date received : 19 February 2020

Date accepted : 27 August 2020

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100003453, Natural Science Foundation of Guangdong Province;

Award ID: 2018A030313605

Award Recipient : Chuan Nie

Funded by: Guangzhou Science and Technology Program

Award ID: 201804010090

Award Recipient : Chuan Nie

Custom metadata

ScienceOpen disciplines: Immunology

Keywords: penicillin allergy,vaginal microbiome,co-abundance network,neonatal health,16s rrna sequencing

Data availability:

ScienceOpen disciplines: Immunology

Keywords: penicillin allergy, vaginal microbiome, co-abundance network, neonatal health, 16s rrna sequencing

Altered vaginal microbiome and relative co-abundance network in pregnant women with penicillin allergy

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Abstract

Background

Methods

Results

Conclusions

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CHAIN Network Collection

Most cited references 31

Low gut microbiota diversity in early infancy precedes asthma at school age.

Low diversity of the gut microbiota in infants with atopic eczema.

Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age.

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