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      Antiserum to LH-RH Blocks Haloperidol-Induced Hyperprolactinemia in Female Rats

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          We investigated the effect of blocking endogenous LH-RH, by injection of anti-LH-RH sera, on serum prolactin levels previously elevated by treatment with haloperidol for 5 days. An acute intravenous injection of rabbit anti-LH-RH serum significantly reduced serum LH levels and blocked the hyperprolactinemia induced by haloperidol. In another group of rats, sheep anti-LH-RH serum induced a significant decrease of serum LH and also lowered serum prolactin levels previously elevated by haloperidol. In ovariectomized rats, sheep anti-LH-RH serum markedly reduced serum LH levels and also decreased serum prolactin elevated by the pretreatment with haloperidol. It is concluded that the blocking of endogenous LH-RH action results in a decreased release of prolactin in response to stimuli like haloperidol. These results support the possible existence of a paracrine interaction between the pituitary gonadotrophs and lactotrophs.

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          Author and article information

          S. Karger AG
          28 March 2008
          : 40
          : 2
          : 185-187
          Veterans Administration Medical Center and Department of Medicine, Tulane University School of Medicine, New Orleans, La., USA
          124071 Neuroendocrinology 1985;40:185–187
          © 1985 S. Karger AG, Basel

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