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      Complex regulation of decidualization: a role for cytokines and proteases--a review.

      1 , , ,
      Placenta
      Elsevier BV

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          Abstract

          Decidualization of the endometrial stroma is a precondition for successful establishment of pregnancy. While the local molecular mechanisms driving decidualization are still largely unknown, a number of autocrine/paracrine factors have been identified as differentiation factors in this process. These include the cytokines, interleukin 11, activin A and monoclonal non-specific suppressor factor beta (MNSFbeta). Furthermore, locally produced proteases, including proprotein convertase 6 and matrix metalloproteinases, enable expansion of the tissue and processing of regulatory molecules. This article reviews recent work from our laboratory on the roles of these factors in decidualization.

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          Author and article information

          Journal
          Placenta
          Placenta
          Elsevier BV
          0143-4004
          0143-4004
          Apr 2003
          : 24 Suppl A
          Affiliations
          [1 ] Prince Henry's Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia. lois.salamonsen@med.monash.edu.au
          Article
          S0143400402909288
          10.1053/plac.2002.0928
          12842418
          64f67c18-6908-479e-98a6-90db470f73fb
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