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      Complex regulation of decidualization: a role for cytokines and proteases--a review.

      Planta

      Activins, physiology, Animals, Cytokines, Decidua, enzymology, growth & development, immunology, Endopeptidases, Female, Humans, In Vitro Techniques, Inhibin-beta Subunits, Interleukin-11, Matrix Metalloproteinases, Mice, Pregnancy, Suppressor Factors, Immunologic

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          Abstract

          Decidualization of the endometrial stroma is a precondition for successful establishment of pregnancy. While the local molecular mechanisms driving decidualization are still largely unknown, a number of autocrine/paracrine factors have been identified as differentiation factors in this process. These include the cytokines, interleukin 11, activin A and monoclonal non-specific suppressor factor beta (MNSFbeta). Furthermore, locally produced proteases, including proprotein convertase 6 and matrix metalloproteinases, enable expansion of the tissue and processing of regulatory molecules. This article reviews recent work from our laboratory on the roles of these factors in decidualization.

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          12842418

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