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      Shared principles in NF-kappaB signaling.

      Cell

      Transcription, Genetic, Signal Transduction, metabolism, genetics, NF-kappa B, I-kappa B Proteins, I-kappa B Kinase, Humans, Animals

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          Abstract

          The transcription factor NF-kappaB has served as a standard for inducible transcription factors for more than 20 years. The numerous stimuli that activate NF-kappaB, and the large number of genes regulated by NF-kappaB, ensure that this transcription factor is still the subject of intense research. Here, we attempt to synthesize some of the basic principles that have emerged from studies of NF-kappaB, and we aim to generate a more unified view of NF-kappaB regulation.

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          Journal
          18267068
          10.1016/j.cell.2008.01.020

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