Dual-source computed tomography for evaluating coronary stenosis and left ventricular function

Abstract

This study aimed to evaluate the correlation between coronary stenosis and left ventricular function using dual-source computed tomography (DSCT). DSCT coronary angiography (CAG) was performed on 66 patients with coronary disease and 36 healthy volunteers. The degree of coronary stenosis, end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF) and myocardial mass (MM) were measured for the left ventricle. These values were compared with the results obtained by echocardiography (ECHO) and selective CAG, which were both adopted as controls. The diagnoses of coronary stenosis based on DSCT CAG and those based on selective CAG were not significantly different (P>0.05). Similarly, the values of EDV, ESV, SV or EV measured by DSCT CAG were not significantly different from thoses obtained by ECHO (P>0.05). However, significant differences were observed in the ESV, EF and SV of the severe stenosis group compared with the moderate and mild stenosis groups (both P<0.05). The values of EDV and MM significantly varied between the mild, moderate and severe stenosis groups (P<0.05). DSCT CAG is a highly accurate and highly reproducible method for evaluating the preliminary changes in cardiac function based on the variations of coronary stenosis. Significant changes were detected in the EDV and MM of the moderate stenosis group and in all parameters of the severe stenosis group.