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      Assessing fall risk in osteoporosis patients: a comparative study of age-matched fallers and nonfallers

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          Abstract

          This study aimed to investigate sway parameters and physical activity level of the age/gender-matched older adults with osteoporosis faller and nonfaller patients. By examining these factors, our objective was to understand how these faller and nonfaller groups with osteoporosis differed particularly in terms of balance capabilities and their impact on physical activity levels. We recruited 24 patients with osteoporosis: 12 who reported a fall within a year before recruitment (fallers) and 12 without falls (nonfallers). Given the close association between biochemical markers of musculoskeletal health such as serum calcium, parathyroid hormone (PTH), Vitamin D, and renal function, we compared these markers in both groups. As a result, elderly individuals with osteoporosis and with a history of falls within the preceding year indicated significantly higher sway velocity ( P = 0.012*), sway area ( P < 0.001*), and sway path length ( P = 0.012*). Furthermore, fallers had significantly lower calcium ( P = 0.02*) and Parathyroid hormone (PTH) ( P = 0.02*), as well as higher Alkaline Phosphatase (ALP) ( P = 0.02*) as compared to nonfallers despite similar vitamin D and creatinine levels. In conclusion, diminished biochemical factors in the osteoporosis faller group could possibly cause postural instability resulting in lower physical activity levels in the osteoporosis fall group and increasing the risk of falls.

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          Most cited references57

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          Risk factors for falls among elderly persons living in the community.

          To study risk factors for falling, we conducted a one-year prospective investigation, using a sample of 336 persons at least 75 years of age who were living in the community. All subjects underwent detailed clinical evaluation, including standardized measures of mental status, strength, reflexes, balance, and gait; in addition, we inspected their homes for environmental hazards. Falls and their circumstances were identified during bimonthly telephone calls. During one year of follow-up, 108 subjects (32 percent) fell at least once; 24 percent of those who fell had serious injuries and 6 percent had fractures. Predisposing factors for falls were identified in linear-logistic models. The adjusted odds ratio for sedative use was 28.3; for cognitive impairment, 5.0; for disability of the lower extremities, 3.8; for palmomental reflex, 3.0; for abnormalities of balance and gait, 1.9; and for foot problems, 1.8; the lower bounds of the 95 percent confidence intervals were 1 or more for all variables. The risk of falling increased linearly with the number of risk factors, from 8 percent with none to 78 percent with four or more risk factors (P less than 0.0001). About 10 percent of the falls occurred during acute illness, 5 percent during hazardous activity, and 44 percent in the presence of environmental hazards. We conclude that falls among older persons living in the community are common and that a simple clinical assessment can identify the elderly persons who are at the greatest risk of falling.
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            Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls?

            Postural control is no longer considered simply a summation of static reflexes but, rather, a complex skill based on the interaction of dynamic sensorimotor processes. The two main functional goals of postural behaviour are postural orientation and postural equilibrium. Postural orientation involves the active alignment of the trunk and head with respect to gravity, support surfaces, the visual surround and internal references. Sensory information from somatosensory, vestibular and visual systems is integrated, and the relative weights placed on each of these inputs are dependent on the goals of the movement task and the environmental context. Postural equilibrium involves the coordination of movement strategies to stabilise the centre of body mass during both self-initiated and externally triggered disturbances of stability. The specific response strategy selected depends not only on the characteristics of the external postural displacement but also on the individual's expectations, goals and prior experience. Anticipatory postural adjustments, prior to voluntary limb movement, serve to maintain postural stability by compensating for destabilising forces associated with moving a limb. The amount of cognitive processing required for postural control depends both on the complexity of the postural task and on the capability of the subject's postural control system. The control of posture involves many different underlying physiological systems that can be affected by pathology or sub-clinical constraints. Damage to any of the underlying systems will result in different, context-specific instabilities. The effective rehabilitation of balance to improve mobility and to prevent falls requires a better understanding of the multiple mechanisms underlying postural control.
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              Human balance and posture control during standing and walking

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                Author and article information

                Contributors
                URI : https://loop.frontiersin.org/people/2381979/overviewRole: Role: Role: Role: Role: Role: Role: Role: Role: Role: Role: Role: Role:
                Role: Role: Role: Role: Role: Role: Role: Role: Role: Role: Role:
                URI : https://loop.frontiersin.org/people/516775/overviewRole: Role: Role: Role: Role: Role: Role: Role: Role: Role: Role:
                Journal
                Front Digit Health
                Front Digit Health
                Front. Digit. Health
                Frontiers in Digital Health
                Frontiers Media S.A.
                2673-253X
                10 July 2024
                2024
                : 6
                : 1387193
                Affiliations
                [ 1 ]Locomotion Research Laboratory, School of Biological and Health Systems Engineering, Arizona State University , Tempe, AZ, United States
                [ 2 ]Division of Endocrinology, Mayo Clinic , Scottsdale, AZ, United States
                Author notes

                Edited by: Mauro Giacomini, University of Genoa, Italy

                Reviewed by: Siti Anom Ahmad, Putra Malaysia University, Malaysia

                Patrick J. Lander, Eastern Institute of Technology, New Zealand

                [* ] Correspondence: Thurmon Lockhart thurmon.lockhart@ 123456asu.edu
                [ † ]

                These authors have contributed equally to this work

                Article
                10.3389/fdgth.2024.1387193
                11266042
                39049820
                652035f7-1777-46c8-a9c8-8f3ca99c190b
                © 2024 Moon, Doshi and Lockhart.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 16 February 2024
                : 20 May 2024
                Page count
                Figures: 1, Tables: 2, Equations: 3, References: 58, Pages: 7, Words: 0
                Funding
                Funded by: NSF-Information and Intelligent Systems (IIS) and Smart and Connected Health
                Award ID: 1065442, 1547466, 1065262
                The author(s) declare financial support was received for the research, authorship, and/or publication of this article.
                This research was partially supported by NSF-CNS-2137272 and by NSF-Information and Intelligent Systems (IIS) and Smart and Connected Health (1065442, and 1547466, and secondary 1065262). This study was partially funded by the MORE Foundation (MORE Foundation Professorship) and, Mayo Clinic - ASU Summer Residency Program.
                Categories
                Digital Health
                Original Research
                Custom metadata
                Connected Health

                osteoporosis,falls,elderly,postural stability,physical activity level,age/gender-matched

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