It is well known that helminth parasites have immunomodulatory effects on their hosts. They characteristically cause a skew toward T H2 immunity, stimulate Treg cells while simultaneously inhibiting T H1 and T H17 responses. Additionally, they induce eosinophilia and extensive IgE release. The exact mechanism of how the worms achieve this effect have yet to be fully elucidated; however, parasite-derived secretions and their interaction with antigen presenting cells have been centrally implicated. Herein, we will review the effects of helminth excretory-secretory fractions on dendritic cells and discuss how this interaction is crucial in shaping the host response.