Blog
About

0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Diatrizoate Levels in the Kidney and Lymph Nodes in Acute Renal Failure in the Rat

      , ,

      Nephron

      S. Karger AG

      Diatrizoate, Renal failure, Glycerol, Rat, Lymph nodes

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Acute renal failure was induced in rats by intramuscular injection of glycerol. Concentrations of intravenous 125I-labelled sodium diatrizoate were measured in plasma, renal cortex and medulla, whole kidney and in lymph nodes draining the kidney. Whole kidney concentrations of diatrizoate, which changed little with time, were initially less than 20% of those in control animals. For 30 min after injection, while plasma levels were highest, renal concentrations in acute renal failure were highest in outer cortex. These observations provide further evidence that, though glomerular filtration continues in acute renal failure, it is much reduced. Diatrizoate was observed in renal lymph nodes from control animals and its existence there does not indicate tubular leakage. Smaller amounts were found in lymph nodes in acute renal failure, suggesting insignificant drainage of diatrizoate to renal lymphatics.

          Related collections

          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1974
          1974
          28 November 2008
          : 13
          : 6
          : 443-454
          Affiliations
          Departments of Diagnostic Radiology and Medical Physics, Welsh National School of Medicine and University Hospital of Wales, Cardiff
          Article
          180423 Nephron 1974;13:443–454
          10.1159/000180423
          4431555
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 12
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Lymph nodes, Renal failure, Rat, Diatrizoate, Glycerol

          Comments

          Comment on this article