Diatrizoate Levels in the Kidney and Lymph Nodes in Acute Renal Failure in the Rat

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Abstract

Acute renal failure was induced in rats by intramuscular injection of glycerol. Concentrations of intravenous 125I-labelled sodium diatrizoate were measured in plasma, renal cortex and medulla, whole kidney and in lymph nodes draining the kidney. Whole kidney concentrations of diatrizoate, which changed little with time, were initially less than 20% of those in control animals. For 30 min after injection, while plasma levels were highest, renal concentrations in acute renal failure were highest in outer cortex. These observations provide further evidence that, though glomerular filtration continues in acute renal failure, it is much reduced. Diatrizoate was observed in renal lymph nodes from control animals and its existence there does not indicate tubular leakage. Smaller amounts were found in lymph nodes in acute renal failure, suggesting insignificant drainage of diatrizoate to renal lymphatics.

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Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1974

Publication date (Print): 1974

Publication date (Electronic): 28 November 2008

Volume: 13

Issue: 6

Pages: 443-454

Affiliations

Departments of Diagnostic Radiology and Medical Physics, Welsh National School of Medicine and University Hospital of Wales, Cardiff

Article

Publisher ID: 180423 Other ID: Nephron 1974;13:443–454

DOI: 10.1159/000180423

PubMed ID: 4431555

SO-VID: 652d6b18-c83f-45bc-b30a-cf08e8fbf0cf

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 27 February 1974

Date accepted : 07 June 1974

Page count

Pages: 12

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