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      Effect of Urinary Alkalinization on Renal Changes Produced by Cationic Albumin

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          Abstract

          40-mg doses of human cationic (CA) or anionic (AA) albumin were admistered intravenously to 48 normal female rats. Sodium bicarbonate (NaHCO<sub>3</sub>) was administered to 8 of these animals before CA or AA. Urine alkalinization caused increased renal CA excretion in CA-injected animals, which also showed marked reduction of the intensity of the renal changes produced by CA.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1984
          1984
          04 December 2008
          : 38
          : 4
          : 261-266
          Affiliations
          Teaching and Research Unit of the University Hospital and Department of Pathology, Faculty of Medicine, USP, São Paulo, Brazil; Department of Internal Medicine and Department of Morphology, Faculty of Medicine, USP, Ribeirão Preto, SP, Brazil
          Article
          183320 Nephron 1984;38:261–266
          10.1159/000183320
          6096744
          652ebe3c-333f-4181-bf35-b64e9c5c258a
          © 1984 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 03 February 1984
          Page count
          Pages: 6
          Categories
          Original Paper

          Cardiovascular Medicine,Nephrology
          Cationic albumin,Proteinuria,Tubular damage,Urinary pH
          Cardiovascular Medicine, Nephrology
          Cationic albumin, Proteinuria, Tubular damage, Urinary pH

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