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Impact of effective versus sham continuous positive airway pressure on liver injury in obstructive sleep apnoea: Data from randomized trials.
Ingrid Jullian-Desayes
1
,
2 ,
Renaud Tamisier
1
,
2 ,
Jean-Pierre Zarski
3 ,
Judith Aron-Wisnewsky
4
,
5 ,
Sandrine H Launois-Rollinat
1
,
2 ,
Candice Trocme
6 ,
Patrick Levy
1
,
2 ,
Marie Joyeux-Faure
1
,
2 ,
Jean-Louis Pepin
1
,
2
Feb 2016
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Abstract
Obstructive sleep apnoea (OSA) could be an independent risk factor for non-alcoholic fatty liver disease (NAFLD) occurrence and progression. The impact of continuous positive airway pressure (CPAP) treatment on non-invasive markers of NAFLD has not been studied. The aim of this study was to evaluate the effect of 6-12 weeks of effective CPAP on the FibroMax test (comprising components including the SteatoTest, NashTest and FibroTest) through three randomized sham controlled studies.