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      Diagnostic Accuracy of Endobronchial Ultrasound Transbronchial Needle Aspiration in Lymphoma. A Systematic Review and Meta-Analysis.

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          Rationale: Endobronchial ultrasound with transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive method used to diagnose suspected mediastinal lymph nodes or masses. However, the accuracy of the diagnosis in patients with suspected lymphoma is unclear.Objectives: To evaluate the diagnostic yield of EBUS-TBNA in patients with suspected lymphoma.Methods: A literature search including EMBASE, MEDLINE, Cochrane Library, and Google Scholar was performed by two reviewers. Included articles were evaluated using the QUADAS-2 tool and meta-analysis with a binary method model to compare the sensitivity, specificity, and summary receiver operating characteristic curve in patients with suspected lymphoma.Results: Fourteen studies (425 participants) were pooled in the analysis. EBUS-TBNA reported an overall sensitivity of 66.2% (confidence interval [CI], 55-75.8%; I2 = 76.2%) and specificity of 99.3% (CI, 98.2-99.7%; I2 = 40%). For a new diagnosis of lymphoma, 13 studies including 243 participants reported sensitivity of 67.1% (CI, 54.2-77.9%; I2 = 66.8%) and specificity of 99.6% (CI, 99.1-99.8%; I2 = 0%). For recurrence of lymphoma, 11 studies including 166 participants reported sensitivity of 77.8% (CI, 68.1-85.2%; I2 = 20.2%) and specificity of 99.5% (CI, 98.9-99.8%; I2 = 0%). In the recurrence group, we found the use of rapid onsite examination, sample size, and flow cytometry increased the sensitivity of EBUS-TBNA, albeit a potential source of heterogeneity.Conclusions: EBUS-TBNA has fair sensitivity for identifying a new diagnosis of lymphoma and fair to good sensitivity for identifying recurrence.Trial Registry: PROSPERO CRD42018102773

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          Author and article information

          Ann Am Thorac Soc
          Annals of the American Thoracic Society
          American Thoracic Society
          Nov 2019
          : 16
          : 11
          [1 ] Facultad de Medicina, Universidad San Sebastian, Concepcion, Chile.
          [2 ] Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
          [3 ] Division of Pulmonary, Critical Care and Environmental Medicine, Tulane University, New Orleans, Louisiana.
          [4 ] Division of Pulmonary and Critical Care, Massachusetts General Hospital, Boston, Massachusetts.
          [5 ] Division of Pulmonary and Critical Care, University of Florida, Gainesville, Florida; and.
          [6 ] Division of Pulmonary and Critical Care, Mayo Clinic, Jacksonville, Florida.


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