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Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial

1 , 2 , 3 , 1 , 2 , 4 , 1 , 5 , 1 , 6 , 1 , 7 , 8 , 9 , 1 , 10 , 1 , 11 , 1 , 12 , 1 , 13 , 1 , 14 , 8 , 15 , 1 , 16 , 1 , 17 , 1 , 18 , 1 , 19 , 8 , 20 , 1 , 21 , 1 , 22 , 1 , 23 , 24 , 25 , 26 , 8 , 27 , 28 , 1 , 29 , 1 , 30 , 1 , 31 , 1 , 32 , 1 , 33 , 34 , 35 , 36 , 1 , 2 , 1 , 2 , 1 , 2 , 1 , 2 , 4 , 1 , 5 , 1 , 6 , 1 , 7 , 7 , 8 , 8 , 9 , 1 , 11 , 1 , 13 , 1 , 6 , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , PREDIMED-Plus Investigators

International Journal of Epidemiology

Oxford University Press (OUP)

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      “Mini-mental state”

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        Diagnostic and Statistical Manual of Mental Disorders

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          Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity.

          A cluster of risk factors for cardiovascular disease and type 2 diabetes mellitus, which occur together more often than by chance alone, have become known as the metabolic syndrome. The risk factors include raised blood pressure, dyslipidemia (raised triglycerides and lowered high-density lipoprotein cholesterol), raised fasting glucose, and central obesity. Various diagnostic criteria have been proposed by different organizations over the past decade. Most recently, these have come from the International Diabetes Federation and the American Heart Association/National Heart, Lung, and Blood Institute. The main difference concerns the measure for central obesity, with this being an obligatory component in the International Diabetes Federation definition, lower than in the American Heart Association/National Heart, Lung, and Blood Institute criteria, and ethnic specific. The present article represents the outcome of a meeting between several major organizations in an attempt to unify criteria. It was agreed that there should not be an obligatory component, but that waist measurement would continue to be a useful preliminary screening tool. Three abnormal findings out of 5 would qualify a person for the metabolic syndrome. A single set of cut points would be used for all components except waist circumference, for which further work is required. In the interim, national or regional cut points for waist circumference can be used.
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            Author and article information

            Affiliations
            [1 ]CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
            [2 ]Department of Preventive Medicine and Public Health, University of Navarra, IDISNA, Pamplona, Spain
            [3 ]Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA
            [4 ]Atención Primaria, Servicio Navarro de Salud-Osasunbidea, Pamplona, Spain
            [5 ]Department of Preventive Medicine, University of Valencia, Valencia, Spain
            [6 ]Rovira i Virgili University, Department of Biochemistry and Biotechnology, Human Nutrition Unit, IISPV, Hospital Universitari Sant Joan de Reus, Reus, Spain
            [7 ]Unit of Cardiovascular Risk and Nutrition, Institut Hospital del Mar de Investigaciones Médicas Municipal d’Investigació Mèdica (IMIM), Barcelona, Spain
            [8 ]CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
            [9 ]Miguel Hernandez University, ISABIAL-FISABIO, Alicante, Spain
            [10 ]Clinical Epidemiology and Public Health Department, Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain
            [11 ]University of Navarra, Department of Nutrition, Food Science and Physiology, IDISNA, Pamplona, Spain
            [12 ]Department of Nursing, School of Health Sciences, University of Málaga-IBIMA, Málaga, Spain
            [13 ]Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain
            [14 ]Department of Internal Medicine, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
            [15 ]Department of Preventive Medicine, University of Granada, Granada, Spain
            [16 ]Department of Cardiology, University Hospital Araba, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain
            [17 ]Research Group on Community Nutrition & Oxidative Stress, University of Balearic Islands, Palma de Mallorca, Spain
            [18 ]Virgen de la Victoria Hospital, Department of Endocrinology, University of Málaga, Málaga, Spain
            [19 ]University of Las Palmas de Gran Canaria, Research Institute of Biomedical and Health Sciences (IUIBS), Preventive Medicine Service, Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health Service, Las Palmas, Spain
            [20 ]Institute of Biomedicine (IBIOMED), University of León, León, Spain
            [21 ]Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, Sevilla, Spain
            [22 ]Department of Endocrinology, Fundación Jiménez-Díaz, Madrid, Spain
            [23 ]Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain
            [24 ]CIBER Diabetes y enfermedades Metabólicas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
            [25 ]Department of Endocrinology, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
            [26 ]Nutritional Genomics and Epigenomics Group, IMDEA Food, CEI UAM + CSIC, Madrid, Spain
            [27 ]Division of Preventive Medicine, Faculty of Medicine, University of Jaén, Jaén, Spain
            [28 ]Department of Endocrinology and Nutrition, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), Madrid, Spain
            [29 ]Lipid Clinic, Department of Endocrinology and Nutrition, Institut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain
            [30 ]Eating Disorders Unit, Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Hospitalet del Llobregat, Barcelona, Spain
            [31 ]Department of Basic and Clinical Psychology and Psychobiology, Universitat Jaume I, Castellón de la Plana, Spain
            [32 ]Department of Nutrition and Food Science, Faculty of Pharmacy and Lucio Lascaray Research Center, Universidad del País Vasco (UPV/EHU), Vitoria, Spain
            [33 ]Department of Nutrition, Food Science and Gastronomy, XaRTA, INSA, -UB, School of Pharmacy and Food Science, University of Barcelona, Barcelona, Spain
            [34 ]Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), Madrid, Spain
            [35 ]Department of Biochemistry and Molecular Biology, Faculty of Medicine and Odontology, University Hospital Dr. Peset, University of Valencia, Valencia, Spain
            [36 ]Department of Preventive Medicine, University of Malaga, Malaga, Spain
            Journal
            International Journal of Epidemiology
            Oxford University Press (OUP)
            0300-5771
            1464-3685
            November 22 2018
            November 22 2018
            10.1093/ije/dyy225
            © 2018

            https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model

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