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The action of sodium cromoglycate on 'C' fibre endings in the dog lung.

Author(s): Paul Jackson, Garth I. Richards, Donald M. Dixon

Publication date: 1980-08-31

Journal: British Journal of Pharmacology

Keywords: Airway Resistance, drug effects, Anesthesia, Animals, Capsaicin, pharmacology, Cromolyn Sodium, Dogs, Hemodynamics, Lung, innervation, Lung Compliance, Nerve Endings

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Abstract

The effect has been studied of sodium cromoglycate (SCG) on the activity of 'C' fibre sensory nerve endings in the canine lung. Pretreatment with SCG (100 microgram/kg i.v.) reduced the excitation of these endings by capsaicin (10 microgram/kg i.v.) for approximately 45 min. This property of SCG may explain its ability to suppress certain types of bronchoconstrictor responses in man.

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PubMed ID:: 6775722

PMC ID:: 2044365

Keywords: Airway Resistance,drug effects,Anesthesia,Animals,Capsaicin,pharmacology,Cromolyn Sodium,Dogs,Hemodynamics,Lung,innervation,Lung Compliance,Nerve Endings

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Keywords: Airway Resistance, drug effects, Anesthesia, Animals, Capsaicin, pharmacology, Cromolyn Sodium, Dogs, Hemodynamics, Lung, innervation, Lung Compliance, Nerve Endings

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