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      Pain in sickle cell disease. Rates and risk factors.

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          Abstract

          Acute episodes of pain are the principal symptom of sickle cell disease, but little is known about the epidemiologic features of these episodes or risk factors for them, nor is it known whether patients with high rates of such episodes die prematurely. We prospectively studied the natural history of sickle cell disease in 3578 patients ranging from newborns to persons up to 66 years old who were followed at clinical centers across the United States.

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          Author and article information

          Journal
          N Engl J Med
          The New England journal of medicine
          Massachusetts Medical Society
          0028-4793
          0028-4793
          Jul 04 1991
          : 325
          : 1
          Affiliations
          [1 ] Children's Hospital, Dana-Farber Cancer Institute, Boston, MA.
          Article
          10.1056/NEJM199107043250103
          1710777
          65533daf-013e-4566-9d7a-3577638a9e3e
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