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      Seroprevalencia de anti-VHC en pacientes de la Unidad Regional de Inmunología Clínica del Estado Aragua. 2003-2004 Translated title: Seroprevalence of anti-VHC in patients attend at Clinic Inmunology Regional Unit of Maracay, Venezuela. 2003 - 2004


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          Se determinó la seroprevalencia de anti-VHC en 1615 sueros de pacientes referidos a la Unidad Regional de Inmunología Clínica (URIC) del Estado Aragua, Venezuela. Las muestras de suero fueron colectadas y analizadas mediante un inmunoensayo enzimático (ELISA), siguiendo las instrucciones del fabricante del equipo. En 90 muestras de suero se detectó anti- VHC lo que representó una seroprevalencia de 5,57% de la población estudiada. Predominó ligeramente el género masculino (53,33%), con respecto al femenino (46,67%) y la edad promedio de estos pacientes fue 36,12 años. La mayoría de los pacientes procedían del Municipio Girardot (41,56%). Sólo el 11,24% de los sueros de los pacientes con anti-VHC pertenecían a personas hospitalizadas. Concluyendo que le seroprevalencia de anti-VHC es muy elevada en la población estudiada

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          Abstract The anti-HCV seroprevalence was determined in 1615 serums of patients referred to the Clinic Inmunology Regional Unit of the State Aragua, Venezuela. The samples of serum were collected and analyzed by ELISA test, following the manufacturer’s instruction. In 90 patients anti-HCV was detected, what represented a seroprevalence of 5,57% in the studied population. It prevailed lightly in males (53,33%) with regard to female (48,51%). The age average of these patients was 36,12 years old. Most of the patients came from the Girardot Municipality (41,56%). Only 11,24% of the serums of the patients with anti-HCV belonged to hospitalized people. We conclude that in the studied population the anti-HCV seroprevalence is very high

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          Three broad modalities in the natural history of vertically acquired hepatitis C virus infection.

          Little is known about the natural history of vertically acquired hepatitis C virus (HCV) infection. We performed a large, multicenter, prospective study of children born to HCV-infected women in Europe. Children were considered to be infected on the basis of > or = 2 polymerase chain reaction (PCR) test results positive for HCV RNA and/or test results positive for anti-HCV antibody > 18 months after birth. Two hundred sixty-six children with vertical HCV infection were followed up until a median of 4.2 years of age (range, 3.2 months to 15.9 years of age). Twenty-six children were coinfected with human immunodeficiency virus. Hepatomegaly, the only clinical sign reported, was found in 10% of children and was significantly associated with a high proportion of abnormal alanine transaminase (ALT) levels (adjusted odds ratio [OR], 4.17; 95% confidence interval [CI], 1.67-10.42; P = .002). An estimated 21%-25% of children may have cleared the virus (i.e., had 2 consecutive PCR test results negative for HCV RNA, normal ALT levels, and no clinical signs) at a median age of 14.9 months. A high proportion of positive PCR test results obtained in the first year of life was associated with a lower likelihood of clearance (OR, 9.77; 95% CI, 2.92-32.67; P 1 year old (adjusted OR, 2.92; 95% CI, 1.09-7.80; P = .03). We confirm the low prevalence of HCV-related clinical signs and symptoms among vertically infected children in the first 10-15 years of life. Approximately 20% of children appear to clear the infection, 50% have evidence of chronic asymptomatic infection, and 30% have evidence of chronic active infection. Although viremia and abnormal ALT levels were associated with hepatomegaly, further investigation is necessary before these markers can be used in the clinical management of HCV infection in children.
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            Sexual transmission of hepatitis C virus among patients attending sexually transmitted diseases clinics in Baltimore--an analysis of 309 sex partnerships.

            The prevalence of antibodies to hepatitis C virus (anti-HCV), the behavioral and laboratory-derived risk factors for anti-HCV, and the quantity and homology of HCV RNA were assessed among 1039 non-injection drug-using sexually transmitted disease (STD) patients representing 309 sex partnerships. Thirty-seven (7%) of 555 males and 19 (4%) of 484 females had anti-HCV. In logistic regression analyses, factors associated with anti-HCV included age (P < .001), greater numbers of lifetime sex partners (P = .023), human immunodeficiency virus infection (P < .001), Trichomonas infection (P < .001), cigarette smoking (P < .001), and male homosexual exposure (P = .012). Among couples, females whose sex partners were anti-HCV positive were 3.7 times more likely to have anti-HCV than females whose sex partners were anti-HCV negative (P = .039). The proportion of RNA homology between anti-HCV positive females and their male partners (94%) was higher than among randomly selected patients (82%). Sexual transmission of HCV may contribute to the high prevalence of anti-HCV reported in urban settings.
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              Estimation of the risk of transmission of hepatitis C between spouses in Egypt based on seroprevalence data.

              Transmission of hepatitis C virus (HCV) between spouses could be due to sexual contact, sharing needles, or other routes. There is uncertainty regarding the degree to which HCV is transmitted between spouses. Data from a 1997 cross-sectional serological survey of HCV in two communities in Egypt were used to estimate the risk of transmission between spouses by simultaneously modelling the probabilities of community acquisition and spousal transmission of HCV as functions of known predictors. We estimate that the probability of wife-to-husband transmission was 34% (95% CI: 15-49%) and 10% (95% CI: 0-26%) for anti-HCV-positive wives with and without detectable HCV RNA, respectively. The probability of husband-to-wife transmission was estimated to be 3% (95% CI: 0-13%) and 0% (95% CI: 0-9%) for husbands with and without detectable HCV RNA, respectively, at the time of the survey. There was moderate evidence that the probability of wife-to-husband transmission differed from that of husband-to-wife transmission (P = 0.076), and there was greater risk of transmission from those with detectable RNA at the time of the survey (P = 0.046). We estimate that 6% of those infected acquired HCV from their spouse. Our study results support the possibility that HCV is transmitted between spouses in Egypt. Further research is needed to identify the exact routes of transmission so that preventive measures can be instituted.

                Author and article information

                Revista de la Sociedad Venezolana de Microbiología
                Rev. Soc. Ven. Microbiol.
                Organo Oficial de la Sociedad Venezolana de Microbiología. (Caracas, DF, Venezuela )
                February 2005
                : 25
                : 2
                : 105-108
                [02] Aragua orgname2Departamento de Microbiología de la Universidad de Carabobo, orgdiv1Sede Aragua Venezuela
                [01] Estado Aragua orgname1Unidad Regional de Inmunología Clínica (URIC),
                S1315-25562005000200009 S1315-2556(05)02500209


                : 23 July 2005
                : 10 August 2005
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 21, Pages: 4

                SciELO Venezuela


                Venezuela,seroprevalencia,Hepatitis C,seroprevalence,Hepatitis C virus


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