17 November 2004
Growth hormone, Growth hormone-releasing hormone, Growth hormone-releasing peptide, Ghrelin, Somatostatin, Insulin-like growth factor I, Threefold peptide control pathway, Sex-steroid hormones, Gender, Oestrogen, Oestradiol, Women
Current investigational tools in molecular biology, biochemistry and integrative physiology have revealed an increasing array of signals that influence growth hormone (GH) secretion. The present perspective combines these factors under a simplified final-common pathway model of threefold joint control by GH-releasing hormone, GH-releasing peptide/ghrelin and somatostatin. This concept is highlighted from the viewpoint of sex steroid- and age-dependent modulation of the peptide trilogy listed above.