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      A Tripeptidyl Ensemble Perspective of Interactive Control of Growth Hormone Secretion

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          Abstract

          Current investigational tools in molecular biology, biochemistry and integrative physiology have revealed an increasing array of signals that influence growth hormone (GH) secretion. The present perspective combines these factors under a simplified final-common pathway model of threefold joint control by GH-releasing hormone, GH-releasing peptide/ghrelin and somatostatin. This concept is highlighted from the viewpoint of sex steroid- and age-dependent modulation of the peptide trilogy listed above.

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          Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human

          A Giustina (1998)
          Article 0 comments Cited 68 times – based on 0 reviews     Review now
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            Endocrine Activities of Ghrelin, a Natural Growth Hormone Secretagogue (GHS), in Humans: Comparison and Interactions with Hexarelin, a Nonnatural Peptidyl GHS, and GH-Releasing Hormone

            E Arvat (2001)
            Article 0 comments Cited 31 times – based on 0 reviews     Review now
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              The Expression of the Growth Hormone Secretagogue Receptor Ligand Ghrelin in Normal and Abnormal Human Pituitary and Other Neuroendocrine Tumors

              M. Korbonits (2001)
              Article 0 comments Cited 22 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (publisher-id): HRE
                Journal ID (nlm-ta): Horm Res Paediatr
                Journal ID (doi): 10.1159/issn.1663-2818
                Title: Hormone Research in Paediatrics
                Publisher: S. Karger AG
                ISBN: 978-3-8055-7609-3
                ISBN: 978-3-318-00998-9
                ISSN (Print): 1663-2818
                ISSN (Electronic): 1663-2826
                Publication date Subscription-year: 2003
                Publication date (Print): July 2003
                Publication date (Electronic): 17 November 2004
                Volume: 60
                Issue: Suppl 1
                Pages: 86-101
                Affiliations
                Mayo Medical and Graduate School of Medicine, Mayo Clinic, Rochester, Minn., USA
                Article
                Publisher ID: 71232 Other ID: Horm Res 2003;60(suppl 1):86–101
                DOI: 10.1159/000071232
                PubMed ID: 12955024
                SO-VID: 6566da51-1f02-45b2-91fc-75a35c5ef641
                Copyright © © 2003 S. Karger AG, Basel
                License:

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                Page count
                Figures: 12, References: 83, Pages: 16
                Categories
                Subject: Somatopause and Elderly GHD – Similarities and Differences

                ScienceOpen disciplines: Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
                Keywords: Oestradiol,Oestrogen,Growth hormone-releasing peptide,Threefold peptide control pathway,Ghrelin,Women,Growth hormone-releasing hormone,Sex-steroid hormones,Gender,Insulin-like growth factor I,Somatostatin,Growth hormone
                Data availability:
                ScienceOpen disciplines: Endocrinology & Diabetes, Neurology, Nutrition & Dietetics, Sexual medicine, Internal medicine, Pharmacology & Pharmaceutical medicine
                Keywords: Oestradiol, Oestrogen, Growth hormone-releasing peptide, Threefold peptide control pathway, Ghrelin, Women, Growth hormone-releasing hormone, Sex-steroid hormones, Gender, Insulin-like growth factor I, Somatostatin, Growth hormone

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