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      Novel Coronavirus: Hypothesis of Treatment with SIRT1 Inhibitors

      working paper

      Kira Smith

      Zenodo

      Coronavirus, Covid-19, Covid, Sars-Cov-2, Coronavirus replication, SIRT1, Sirtuines

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          Abstract

          Sirtuin 1 SIRT1 inhibitors can be a valid solution to treat Novel Coronavirus, based on research on reduction of many virus replication and growth, as Mers-CoV, HIV, Epathitis B, VSV (Vesicular Stomatitis Virus), flu strains, adenovirus and others. SIRT1/SIRT2 inhibitors are related to the halt of cells' apoptotic response. In addition, SIRT1 reduce ACE2 activity, the receptor which Coronavirus uses to enter in the host's cells.

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          Author and article information

          Journal
          Zenodo
          2020
          03 August 2020
          Article
          10.5281/zenodo.3971140

          Creative Commons Attribution 4.0 International

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