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      Refining the definition of hypereosinophilic syndrome

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          Abstract

          Because of advances in our understanding of the hypereosinophilic syndrome (HES) and the availability of novel therapeutic agents, the original criteria defining these disorders are becoming increasingly problematic. Here, we discuss shortcomings with the current definition of HES and recent developments in the classification of these disorders. Despite significant progress in our understanding of the pathogenesis of some forms of HES, the current state of knowledge is still insufficient to formulate a new comprehensive etiologic definition of HESs. Nevertheless, we suggest a new working definition that overcomes some of the most obvious limitations with the original definition.

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          Author and article information

          Journal
          Journal of Allergy and Clinical Immunology
          Journal of Allergy and Clinical Immunology
          Elsevier BV
          00916749
          July 2010
          July 2010
          : 126
          : 1
          : 45-49
          Article
          10.1016/j.jaci.2010.03.042
          3400024
          20639008
          © 2010

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