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The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.

Science (New York, N.Y.)

therapeutic use, Alzheimer Disease, pharmacology, Sirolimus, physiopathology, genetics, drug therapy, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Phenothiazines, Oligonucleotide Array Sequence Analysis, Obesity, Limonins, Humans, Histone Deacetylase Inhibitors, antagonists & inhibitors, HSP90 Heat-Shock Proteins, Gene Expression Profiling, drug effects, Gene Expression, Estrogens, Enzyme Inhibitors, Drug Resistance, Neoplasm, methods, Drug Evaluation, Preclinical, Dexamethasone, Databases, Factual, Cell Line, Tumor, Cell Line, Software

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      Abstract

      To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this "Connectivity Map" resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

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      Journal
      10.1126/science.1132939
      17008526

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