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      Neuroprotective effect of a new synthetic aspirin-decursinol adduct in a rat model of ischemic stroke

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      1 , , 1 , 1 , 1
      Critical Care
      BioMed Central
      33rd International Symposium on Intensive Care and Emergency Medicine
      19-22 March 2013

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          Abstract

          Introduction Stroke is a major cause of death. This study investigated the preventative effect of a new synthetic drug on brain function in experimentally induced ischemic stroke. Methods Male Sprague-Dawley rats were administered aspirin (ASA), decursinol (DA) or ASA-DA before and after ischemic insults. Brain and neuronal damage were examined by TTC staining, PEP-CT, NeuN immunohistochemistry and F-J B histofluorescence. Gliosis was also observed by GFAP and iba-1 immunohistochemistry. Results Pretreatment with 20 mg/kg, but not 10 mg/kg, of ASA-DA protected against ischemic neuronal death and damage, and its neuroprotective effect was much more pronounced than that of ASA or DA alone. In addition, treatment with 20 mg/kg ASA-DA reduced the ischemia-induced activation of astrocytes and microglia. Conclusion Our findings indicate that ASA-DA, a new synthetic drug, prevents against transient focal cerebral ischemia, which provides a resource for the development of its clinical application for stroke.

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          Author and article information

          Conference
          Crit Care
          Crit Care
          Critical Care
          BioMed Central
          1364-8535
          1466-609X
          2013
          19 March 2013
          : 17
          : Suppl 2
          : P345
          Affiliations
          [1 ]Kangwon National University, Chuncheonsi, South Korea
          Article
          cc12283
          10.1186/cc12283
          3642797
          659f0744-7472-4f0b-896c-be2e1af942f7
          Copyright ©2013 Lee et al.; licensee BioMed Central Ltd.

          This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

          33rd International Symposium on Intensive Care and Emergency Medicine
          Brussels, Belgium
          19-22 March 2013
          History
          Categories
          Poster Presentation

          Emergency medicine & Trauma
          Emergency medicine & Trauma

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