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      NF-κB signaling pathways: role in nervous system physiology and pathology.

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          Abstract

          Intracellular pathways related to cell survival regulate neuronal physiology during development and neurodegenerative disorders. One of the pathways that have recently emerged with an important role in these processes is nuclear factor-κB (NF-κB). The activity of this pathway leads to the nuclear translocation of the NF-κB transcription factors and the regulation of anti-apoptotic gene expression. Different stimuli can activate the pathway through different intracellular cascades (canonical, non-canonical, and atypical), contributing to the translocation of specific dimers of the NF-κB transcription factors, and each of these dimers can regulate the transcription of different genes. Recent studies have shown that the activation of this pathway regulates opposite responses such as cell survival or neuronal degeneration. These apparent contradictory effects depend on conditions such as the pathway stimuli, the origin of the cells, or the cellular context. In the present review, the authors summarize these findings and discuss their significance with respect to survival or death in the nervous system.

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          Author and article information

          Journal
          Neuroscientist
          The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
          1089-4098
          1073-8584
          Apr 2013
          : 19
          : 2
          Affiliations
          [1 ] Neuronal Signaling Unit, Dep. Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida-IRBLLEIDA, Lleida, Spain.
          Article
          1073858412444007
          10.1177/1073858412444007
          22785105
          65a21a4c-cbbd-4704-845a-babe37b117e8
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