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      Effect of P2Y12 Inhibitor Monotherapy vs Dual Antiplatelet Therapy on Cardiovascular Events in Patients Undergoing Percutaneous Coronary Intervention : The SMART-CHOICE Randomized Clinical Trial

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          Abstract

          Data on P2Y12 inhibitor monotherapy after short-duration dual antiplatelet therapy (DAPT) in patients undergoing percutaneous coronary intervention are limited.

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          Most cited references17

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          Ticagrelor plus aspirin for 1 month, followed by ticagrelor monotherapy for 23 months vs aspirin plus clopidogrel or ticagrelor for 12 months, followed by aspirin monotherapy for 12 months after implantation of a drug-eluting stent: a multicentre, open-label, randomised superiority trial

          We hypothesised that ticagrelor, in combination with aspirin for 1 month, followed by ticagrelor alone, improves outcomes after percutaneous coronary intervention compared with standard antiplatelet regimens.
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            Long-Term Safety of Drug-Eluting and Bare-Metal Stents: Evidence From a Comprehensive Network Meta-Analysis.

            Previous meta-analyses have investigated the relative safety and efficacy profiles of different types of drug-eluting stents (DES) and bare-metal stents (BMS); however, most prior trials in these meta-analyses reported follow-up to only 1 year, and as such, the relative long-term safety and efficacy of these devices are unknown. Many recent studies have now reported extended follow-up data.
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              6-month versus 12-month or longer dual antiplatelet therapy after percutaneous coronary intervention in patients with acute coronary syndrome (SMART-DATE): a randomised, open-label, non-inferiority trial

              Current guidelines recommend dual antiplatelet therapy (DAPT) of aspirin plus a P2Y12 inhibitor for at least 12 months after implantation of drug-eluting stents (DES) in patients with acute coronary syndrome. However, available data about the optimal duration of DAPT in patients with acute coronary syndrome undergoing percutaneous coronary intervention are scant. We aimed to investigate whether a 6-month duration of DAPT would be non-inferior to the conventional 12-month or longer duration of DAPT in this population.
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                Author and article information

                Journal
                JAMA
                JAMA
                American Medical Association (AMA)
                0098-7484
                June 25 2019
                June 25 2019
                : 321
                : 24
                : 2428
                Affiliations
                [1 ]Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
                [2 ]Department of Cardiology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea
                [3 ]Division of Cardiology, Dongsuwon General Hospital, Suwon, Korea
                [4 ]Chungnam National University Hospital, Daejeon, Korea
                [5 ]Division of Cardiology, Kangwon National University Hospital, Chuncheon, Korea
                [6 ]Department of Cardiovascular Medicine, Regional Cardiocerebrovascular Center, Wonkwang University Hospital, Iksan, Korea
                [7 ]Division of Cardiology, Department of Internal Medicine, Myongji Hospital, Goyang, Korea
                [8 ]Division of Cardiology, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
                [9 ]Department of Internal Medicine, Chosun University Hospital, Gwangju, Korea
                [10 ]Department of Internal Medicine, College of Medicine, Chungbuk National University Hospital, Cheongju, Korea
                [11 ]Eulji General Hospital, Seoul, Korea
                [12 ]Chung-Ang University Hospital, Seoul, Korea
                [13 ]Keimyung University Dongsan Medical Center, Daegu, Korea
                [14 ]Kwangju Christian Hospital, Gwangju, Korea
                [15 ]St Carollo Hospital, Suncheon, Korea
                [16 ]Konkuk University Chungju Hospital, Chungju, Korea
                [17 ]Korea University Guro Hospital, Seoul, Korea
                Article
                10.1001/jama.2019.8146
                6593635
                31237645
                65a585df-2a84-4ccb-b446-e8e015b08cd7
                © 2019
                History

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