Multi-institutional external validation of urinary TWIST1 and NID2 methylation as a diagnostic test for bladder cancer.

Fantony, Joseph J.; Abern, Michael R.; Gopalakrishna, Ajay; Owusu, Richmond A.; Jack Tay, Kae; Lance, Raymond S; Inman, Brant A

doi:10.1016/j.urolonc.2015.04.014

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Multi-institutional external validation of urinary TWIST1 and NID2 methylation as a diagnostic test for bladder cancer.

Author(s): Joseph J Fantony ¹ , Michael R Abern ² , Ajay Gopalakrishna ¹ , Richmond Owusu ¹ , Kae Jack Tay ¹ , Raymond S Lance ³ , Brant A Inman ⁴

Publication date (Electronic): Sep 2015

Journal: Urologic oncology

Publisher: Elsevier BV

Keywords: Diagnostic test, Epigenetic, Sensitivity, Smoking, Specificity, Urothelial carcinoma

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Abstract

We previously reported a clinical trial in which we were unable to replicate the excellent diagnostic metrics produced in the developmental study of the TWIST1 and NID2 gene methylation assay. In this expanded trial with subjects enrolled from another institution, we reexamine the diagnostic capabilities of the test to externally validate our previous study.

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Journal ID (iso-abbrev): Urol. Oncol.

Title: Urologic oncology

Publisher: Elsevier BV

ISSN (Electronic): 1873-2496

ISSN (Print): 1078-1439

Publication date (Electronic): Sep 2015

Volume: 33

Issue: 9

Affiliations

[1 ] Division of Urology, Duke University Medical Center, Durham, NC.

[2 ] Department of Urology, University of Illinois Chicago, Chicago, IL.

[3 ] Division of Urology, Urology of Virginia, Virginia Beach, VA.

[4 ] Division of Urology, Duke University Medical Center, Durham, NC. Electronic address: brant.inman@duke.edu.

Article

Publisher Item ID: S1078-1439(15)00193-3

DOI: 10.1016/j.urolonc.2015.04.014

PubMed ID: 26027762

SO-VID: 65c022d5-3927-4ec1-8312-9c24c644cf38

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Keywords: Diagnostic test,Epigenetic,Sensitivity,Smoking,Specificity,Urothelial carcinoma

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Keywords: Diagnostic test, Epigenetic, Sensitivity, Smoking, Specificity, Urothelial carcinoma

Multi-institutional external validation of urinary TWIST1 and NID2 methylation as a diagnostic test for bladder cancer.

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