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      A new homatropine potentiometric membrane sensor as a useful device for homatropine hydrobromide analysis in pharmaceutical formulation and urine: a computational study

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          Abstract

          Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is available as the hydrobromide or methylbromide salt. In this study, a potentiometric liquid membrane sensor for simple and fast determination of homatropine hydrobromide in pharmaceutical formulation and urine was constructed. For the membrane preparation, homatropine-tetraphenylborate complexes were employed as electroactive materials in the membrane. The proposed sensor presents wide linear range (10-5-10-1 mol L-1), low detection limit (8×10-6 mol L-1), and fast response time (ca. 10 s). Validation of the method shows suitability of the sensors for applicability in the quality control analysis of homatropine hydrobromide in pharmaceutical formulation and urine.

          Translated abstract

          Homatropina ('Equipin, Isopto Homatropine') é um medicamento anticolinérgico que inibe receptores muscarínicos de acetilcolina e, consequentemente, o sistema nervoso parassimpático. É encontrado na forma de sal, bromoidrato ou metilbrometo. Neste estudo, foi construído um sensor potenciométrico de membrana líquida para determinação rápida e simples de bromoidrato de homatropina em formulações farmacêuticas e em urina. Para a preparação da membrana, complexos homatropina-tetrafenilborato foram empregados como materiais eletroativos na membrana. O sensor proposto apresenta um intervalo linear amplo (10-5-10-1 mol L-1), baixo limite de detecção (8 × 10-6 mol L-1), e resposta rápida (ca. 10 s). A validação do método mostra que os sensores são adequados para aplicação em análises de controle de qualidade de bromoidrato de homatropina em formulações farmacêuticas e urina.

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          Most cited references 36

          • Record: found
          • Abstract: not found
          • Article: not found

          Chemical routes for the transformation of biomass into chemicals.

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            • Record: found
            • Abstract: not found
            • Article: not found

            Transition Metal Oxides

             C N R Rao (1989)
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              • Record: found
              • Abstract: not found
              • Article: not found

              J. Comp. Chem.

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                jbchs
                Journal of the Brazilian Chemical Society
                J. Braz. Chem. Soc.
                Sociedade Brasileira de Química (São Paulo )
                1678-4790
                2009
                : 20
                : 5
                : 926-934
                Affiliations
                [1 ] University of Tehran Iran
                [2 ] University of Tehran Iran
                Article
                S0103-50532009000500018
                10.1590/S0103-50532009000500018

                http://creativecommons.org/licenses/by/4.0/

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                Product Information: website
                Categories
                CHEMISTRY, MULTIDISCIPLINARY

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