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      A Three-Dimensional Quantitative Analysis of Restenosis Parameters after Balloon Angioplasty: Comparison between Semi-Automatic Computer-Assisted Planimetry and Stereology


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          Semi-automatic computer-assisted planimetry is often used for the quantification of restenosis parameters after balloon angioplasty although it is a time-consuming method. Moreover, slicing the artery to enable analysis of two-dimensional (2-D) images leads to a loss of information since the vessel structure is three-dimensional (3-D). Cavalieri’s principle uses systematic random sampling allowing 3-D quantification. This study compares the accuracy and efficiency of planimetry versus point-counting measurements on restenosis parameters after balloon angioplasty and investigates the use of Cavalieri’s principle for 3-D volume quantification. Bland and Altman plots showed good agreement between planimetry and point counting for the 2-D and 3-D quantification of lumen, internal elastic lamina (IEL) and external elastic lamina (EEL), with a slightly smaller agreement for intima and media. Mean values and induced coefficients of variation were similar for both methods for all parameters. Point counting induced a 6% error in its 3-D quantification, which is negligible in view of the biological variation (>90%) among animals. However, point counting was 3 times faster compared to planimetry, improving its efficiency. This study shows that combining Cavalieri’s principle with point counting is a precise and efficient method for the 3-D quantification of restenosis parameters after balloon angioplasty.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          October 2002
          18 September 2002
          : 39
          : 5
          : 437-446
          aDivisions of Cardiology and bPharmacology, University of Antwerp (UIA), Wilrijk, and cHistoGeneX, Antwerp, Belgium
          64514 J Vas Res 2002;39:437–446
          © 2002 S. Karger AG, Basel

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          Page count
          Figures: 3, Tables: 5, References: 35, Pages: 10
          Research Paper


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