Six New Phragmalin Limonoids from the Stems of Chukrasia tabularis A. Juss

Abstract

Six new phragmalin limonoids, named moluccensin Z1 ( 1), moluccensin Z2 ( 2), carapanolide Y ( 3), tabulalin N ( 4), chukvelutilide A1 ( 5), and velutinasin J ( 6), as well as two known compounds, chukvelutilide A ( 7) and velutinasin D ( 8) were isolated from the stems of Chukrasia tabularis A. Juss. The structures of the new compounds 1– 6 were confirmed by spectroscopic methods, including IR and HRESIMS, as well as 1D and 2D NMR, and by comparisons with the data of known analogues. All compounds were tested for α-glucosidase and acetylcholinesterase inhibitory activities. However, none of the compounds was active against α-glucosidase and acetylcholinesterase in vitro.