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      Dopaminergic Involvement in Intraocular Pressure in the Rabbit Eye

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          Abstract

          The involvement of dopamine in maintaining intraocular pressure (IOP) was investigated with the rabbit IOP recovery model after intravenous infusion of hypertonic saline. Dopamine facilitated the IOP recovery while reserpine did the opposite. When dopamine was administered after reserpinization, the IOP recovery was facilitated again. These results indicate that dopamine is involved in the maintenance of IOP because depletion of dopamine with reserpine resulted in an opposite effect produced by dopamine whereas administration of dopamine in reserpinized animals induced dopaminergic responses. Timolol produced similar effects as reserpine, which supports the idea that timolol reduces aqueous humor formation through elimination of dopaminergic function and reduction of blood flow in the ciliary body.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1983
          1983
          04 December 2009
          : 15
          : 3
          : 131-135
          Affiliations
          Department of Medical Pharmacology and Toxicology, Texas A & M University College of Medicine, College Station, Tex., USA
          Article
          265247 Ophthalmic Res 1983;15:131–135
          10.1159/000265247
          6634049
          © 1983 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

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