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Low dose LPS does not increase TLR4 expression on monocytes in a human in vivo model
Philipp Lichte ,
Jan-Sebastian Grigoleit ,
Eva Maria Steiner ,
Jennifer S. Kullmann ,
Manfred Schedlowski ,
Reiner Oberbeck ,
Philipp Kobbe
July 2013
July 2013
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Abstract
Toll like receptor 4 (TLR4) is the major recognition receptor for lipopolysaccharides
and plays a major role in the inflammatory response. CD11b is expressed on the surface
of many leukocytes including monocytes. The CD11b/CD18 complex is involved in the
inflammatory response by mediating migration and adhesion of leukocytes. The aim of
this human in vivo study was to investigate the expression of TLR4 and CD11b on the
surface of human monocytes after in vivo low-dose LPS stimulation.